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"Advanced 2D CELL culture for improved Phenotype assays"

The CELPPLUS team has developed cell culture wells that make cells feel more at home in the lab.

During the 2 year project (2021-2023), the team used nanotechnological approaches to deposit protein patterns on the bottom of cell culture wells. The purpose was to make the cells feel at home, because - similar to humans - they behave differently when they are not at home. If the cells in the lab don't mimic the behaviour of the cells in our body, it is very difficult to translate reserach results from the lab to a clinical setting.

Therefore, by placing,  proteins from the cells' natural environment on the surface of the culture wells, the CELPPLUS team makes sure that the cells receive signals that better mimic their natural environment in the human body.

Further below, you will find a link to the CELPPLUS video recorded at the beginning of the project. You can also read an article on how the CELPPLUS team developed the cell culture wells and what their hopes are for future collaborations on the CELPPLUS assay.

"It’s our aim for the CELPPLUS assay to help researchers make better and more relevant results using cell assays. We hope that the CELPPLUS assay can become a standard assay in both research labs and in the drug discovery pipeline."


Duncan Sutherland, Head of the CELPPLUS project


Academic team members

  • Duncan Sutherland, Professor, Aaarhus University
  • Claus Johansen, Assoc. Professor, Aaarhus University (Hospital)

Industrial team member

  • Andreas Herchenhan, LEO Pharma

"Cells are social. Inside the body, they interact with each other and their surroundings all the time and they receive a lot of signals that tell them how to behave. As soon as you remove them from the body, the signals changes and so does their behavior.

When we can control the pattern of proteins on the surface of plastic culture wells, we also have control of the signals that the cells sense. In this way, we can control how cells behave in the lab and thus make them better models for the human body."


Duncan Sutherland, Head of the CELPPLUS project


  1. Shahrokhtash A et al. 2023. Microplate Format Protein Nanopatterning for High-Throughput Screening of Cellular Microenvironments. Preprint. doi: https://doi.org/10.1101/2023.11.19.567703


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The 5-year platform is sponsored by the Novo Nordisk Foundation with 180 M DKK from 2024-2028.


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