Aim
To identify blood biomarkers in patients suffering from MASH. The biomarkers can potentially help diagnose patients, predict disease development, and monitor treatment responses.
Approach
The oLIVER project team is using an approach called APTASHAPE. By mixing a blood sample with millions of small RNA biosensors, the team can generate a digital 'picture' of the blood sample's composition. By 'taking pictures' of different blood samples, the APTASHAPE approach can help researchers find out, which molecular changes are taking place during disease.
Outcome
The oLIVER team identified potential biomarkers and drug targets for metabolic dysfunction-associated steatotic liver disease (MASLD) using the APTASHAPE platform. By analyzing blood plasma samples from patients and healthy controls, the team identified distinct molecular "fingerprints" associated with liver disease. These findings provide a foundation for developing blood-based tools to support diagnosis, prognosis, and treatment monitoring in MASLD.
On this page, you can watch a video recorded at the beginning of the oLIVER project. You can also read an article on the output of the project or read a short cartoon story about the aim of the project.
THE oLIVER TEAM
Academic team members
- Jørgen Kjems, Professor, Aarhus University
- Henning Grønbæk, Professor, Aaarhus University Hospital
- Christian B. Vægter, Assoc. Professor, Aarhus University
- Daniel Miotto Dupont
- Søren Fjelstrup
- Mikkel Breinholt Kjær
- Asger Givskov Jørgensen
Industrial team member
- Natasha Barascuk Michaelsen, Novo Nordisk
ABOUT ODIN
We unite bright minds from industry and academia to jointly create need-driven clinical research projects - and pave the way for innovative new treatments and diagnostics. We fund the best project ideas through competitive funding calls. Although companies cannot receive funding, it is free of charge to join.
The platform is sponsored by the Novo Nordisk Foundation with 180 million DKK from 2024-2029.
CONTACT ODIN
You are welcome to contact us if you have questions or comments. Reach out to odin@au.dk or find the Secretariat's direct email addresses under contacts.
Although the platform spans five Danish universities, we're based in Aarhus. Our office is located at Aarhus University, Ny Munkegade 116, Bldg 1535-117.
