Aim
The aim of the KidDO project was bipartite: First, the team identified metabolites that can predict progression of chronic kidney disease (CKD). Second, they also studied how the interplay between metabolites and proteins within the kidneys drives this progression.
Approach
The KidDO project focused on changes in metabolites in the kidney during chronic kidney disease. The team used different omics strategies to identify metabolites and proteins that were altered at different stages of CKD, and to see how they interacted and affected the progression of the disease.
The KidDO team also evaluated five different animal models and compared them to human samples using machine learning strategies, with the hope of identifying which model system most closely resembles the human disease.
Outcome
During the project (2021–2023), the KidDO team identified metabolites, proteins, and genes consistently altered in chronic kidney disease across human biopsies and experimental models. A key outcome was the development of a large-scale database integrating metabolic and proteomic data, providing a valuable resource for studying disease mechanisms, identifying biomarkers, and supporting future therapeutic development.
On this page, you can watch a video recorded at the beginning of the project. You can also read an article about the project's output and find lists of project participants on the KidDO team.
THE KidDO TEAM
Academic team members
- Robert Fenton, Professor, Aarhus University
- Ira Assent, Professor, Aarhus University
- Markus Rinschen, Assoc. Professor, Aarhus University
- Ken Howard, Assoc. Professor, Aarhus University
- Qi Wu, Assoc. Professor, Aarhus University
- Anja Billing, Assist. Professor, Aarhus University
Industrial team member
- Pernille Lærkegaard Hansen, AstraZeneca
ABOUT ODIN
We unite bright minds from industry and academia to jointly create need-driven clinical research projects - and pave the way for innovative new treatments and diagnostics. We fund the best project ideas through competitive funding calls. Although companies cannot receive funding, it is free of charge to join.
The platform is sponsored by the Novo Nordisk Foundation with 180 million DKK from 2024-2029.
CONTACT ODIN
You are welcome to contact us if you have questions or comments. Reach out to odin@au.dk or find the Secretariat's direct email addresses under contacts.
Although the platform spans five Danish universities, we're based in Aarhus. Our office is located at Aarhus University, Ny Munkegade 116, Bldg 1535-117.
