Analysing molecular characteristics and their variation during lifestyle changes, by combining digital tools, classical laboratory tests and new biomolecular measurements, could enable individualised prevention of disease. This is according to a new study from Karolinska Institutet in Sweden and the University of Helsinki in Finland published in the journal Cell Systems. The researchers show what a proactive healthcare model could comprise and how it could help in maintaining good health.

A group of Nordic researchers has discovered a novel immune deficiency disease affecting the regulation of the immune system. A mutation in the IKZF2 gene was identified in a Finnish family with recurrent infections and signs of immune overactivation. The results provide a basis for a deeper understanding of the molecular mechanisms behind activation and maturation of T cells and will aid the diagnosis of rare inborn errors of immunity. doi: 10.1126/sciimmunol.abe3454

A functional precision medicine study conducted in Finland demonstrates that treatment selection based on results from drug sensitivity testing of patients' cells can be clinically useful in patients with aggressive hematological cancers.

Latest work from the Bionanotechnology and Membrane Systems group, led by Irep Gözen, has been shared in two pre-prints.

The genetic makeup of an individual contributes to susceptibility and response to viral infection. While environmental, clinical and social factors play a role in exposure to SARS-CoV-2 and COVID-19 disease severity1,2, host genetics may also be important.

COVID-19 is a complex disease targeting many organs. Previous studies highlight COVID-19 as a probable risk factor for acute cardiovascular complications. We aimed to quantify the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19 by analysing all COVID-19 cases in Sweden.

Fresh uncultured tumor-derived epithelial cells (FUTCs) are amenable for drug testing.

Profiling of lung tumor and matched normal cells identifies cancer-selective treatments

NSCLC FUTCs with targetable drivers expose genotype-matched responses or non-responses. The FUTC approach can guide personalized therapy in compassionate patient care

Bacterial pathogens have to cope with stressful environments in human host. Their response with the activity of gene products enables them to adapt to those stressful environments and cause troublesome infections. Therefore, genes involved in the adaptation are potential targets for new antimicrobials.

The Luecke Group at NCMM have published in the journal Nature Communications