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We will collate and update the existing global knowledge base on the available methods for the assessment of cationic polymers toxicity, fate properties as well as regarding their known descriptors used to develop Structure Activity Relationships for these materials. The data will be used to organize and group the cationic polymers for further categorization and assessments. Based on initial screenings of the literature and the industry findings safety data, the cationic polymers that are our initial focus of continued evaluation are polyquaterniums 6, 7, 10 and 16. These polyquaterniums have widespread usage across the consumer products industry, therefore the potential for environmental exposure is high.