New publication: Iron Stress Reprograms Enterocyte Metabolism

🚨 New Publication from PIG-PARADIGM! 🚨

We are excited to share another new article from the PIG-PARADIGM consortium, authored by PhD student Shya Navazesh from the Peng Ji lab at the Department of Nutrition, University of California Davis.

This study utilized IPEC-J2, a neonatal pig jejunum-derived cell line, to assess how iron deficiency and excess alter enterocyte metabolism and the transcription of inflammatory markers. We found that iron deficiency impaired enterocyte proliferation and profoundly disrupted cellular metabolism, whereas excess enhanced cholesterol synthesis and depleted alpha-tocopherol levels. Restoration of cellular metabolism was observed following iron repletion, highlighting the resilience of enterocytes.

📖 Read the full article here: https://doi.org/10.3390/metabo15110691

👉You can also read our recent interview with Shya about her work.