Research Technology and Core Facility Services

These technology platforms and core facilities serve researchers from both within and outside of their host institutions. They are all open to use by researchers at each node of the Nordic EMBL Partnership, and some are open to researchers from outside of the Partnership.

Extracellular vesicles

Extracellular Vesicles Core (FIMM)

Extracellular Vesicles (EV) Core is the world’s first technology platform dedicated to Extracellular Vesicle isolation and analytics. The EV Core is divided into two units. EV Core FIMM focuses on EVs from liquid biopsy samples, including isolation and analysis of EV-RNA as well as electron microscopy samples. EV Core Viikki is dedicated to the characterization of EVs using NTA and Apogee micro flow cytometer, and functional assays.

Read more.

Genomics

Extracellular Vesicles Core (FIMM)

Extracellular Vesicles (EV) Core is the world’s first technology platform dedicated to Extracellular Vesicle isolation and analytics. The EV Core is divided into two units. EV Core FIMM focuses on EVs from liquid biopsy samples, including isolation and analysis of EV-RNA as well as electron microscopy samples. EV Core Viikki is dedicated to the characterization of EVs using NTA and Apogee micro flow cytometer, and functional assays.

Read more. 

Genomics (FIMM)

FIMM Genomics provides open-access DNA/RNA sequencing and genotyping services for researchers in Finland and abroad.

Read more.

HiPrep Core (FIMM)

HiPrep core is a new service unit of the FIMM Technology Centre. It offers RNA isolation or preparation services for both academic and industry customers. HiPrep core develops workflows for preparation of high-quality nucleic acids from various biological samples in close collaboration with the FIMM sequencing and single cell analytics units and the EV Core.

Read more

Single Cell Analytics (FIMM)

FIMM Single Cell Analytics (SCA) unit develops and provides single cell transcriptomics services nationally and internationally. The unit collaborates closely with the FIMM Genomics Sequencing unit as well as with the FIMM Technology Centre IT Services, Digital Microscopy and Molecular Pathology unit and High Through­put Biomedicine unit.

FIMM Single-Cell Analytics is a non-profit academic core facility. We are part of HILIFE and Biocenter Finland Single-Cell omics networks.

Read more.

High-throughput screening

Chemical Biology Screening: High-Throughput Screening Platform (NCMM)

The Chemical Biology Screening unit enables researchers to discover small molecules to probe, explore and modulate biological systems through high-throughput screening of small molecules. It also providers assay development assistance and data management services.

Read more.

High Throughput Biomedicine Unit (FIMM)

The High Throughput Biomedicine Unit (HTB) provides high throughput screening approaches of many types, such as Drug Sensitivity and Resistance testing (DSRT assay), siRNA screening, Cell-based and biochemical screens, Molecular probe discovery, Biological profiling using libraries of known bioactives, Drug repositioning, and Personalized medicine screening (drug resistance and sensitivity) using approved and investigational drugs. 

Read more. 

Imaging & microscopy

The JOINT - Electrophysiology, optogenetics and behaviour (DANDRITE)

The JOINT is an interactive workshop facility based at the Department of Biomedicine, Aarhus University, for neuro-scientific research using electrophysiology, optogenetics, and behavioural experimental setups.

Read more.

 

Biochemical Imaging Centre Umeå (MIMS)

The Biochemical Imaging Centre Umeå, was founded with support from the Swedish Research Council in order to establish a node of excellence for fluorescence super-resolution and live cell imaging. The centre includes equipment for combined use of different advanced imaging techniques to visualise the same sample in multiple ways. Instrumentation includes a spinning disk microscope and a confocal microscope with resonant scanner. Both microscopes are fully equipped for photo-bleaching (FRAP) and photo-quenching (FRET) experiments and TIRF (total internal reflection fluorescence) microscopy. The equipment is completed with a STORM-unit that allows super-resolution imaging of structures and micromanipulators down to 20nm. 

Read more. 

Digital Microscopy and Molecular Pathology Unit (FIMM)

The digital microscopy and molecular pathology unit provides high throughput whole-slide scanning services for all customers. We offer quick, high-quality and cost-efficient wide-field microscope imaging for bright field and fluorescence.

Learn more.

EMBION - The facility (DANDRITE)

EMBION is the research infrastructure for cryo-electron microscopy. The facility offers academic and industrial users access to state of the art cryo-EM equipment and specialist assistance in a plethora of areas including single particle analysis and tomography.

Read more.

Extracellular Vesicles Core (FIMM)

Extracellular Vesicles (EV) Core is the world’s first technology platform dedicated to Extracellular Vesicle isolation and analytics. The EV Core is divided into two units. EV Core FIMM focuses on EVs from liquid biopsy samples, including isolation and analysis of EV-RNA as well as electron microscopy samples. EV Core Viikki is dedicated to the characterization of EVs using NTA and Apogee micro flow cytometer, and functional assays.

Read more.

High Content Imaging and Analysis (FIMM)

FIMM High Content Imaging and Analysis (FIMM-HCA) unit provides services in high-content and high-throughput imaging and image analysis. This new facility is open access core unit, that started operation at the beginning of 2017, with harmonized operating principles, access and user policy within Helsinki Bioimaging, together with BIU-LM, LMU-BI and EMBI. FIMM-HCA is also part of the FIMM technology centre.

Learn more.

Imaging Core Facility at Biomedicine (DANDRITE)

The Bioimaging Core Facility provides state-of-the-art equipment for a wide range of light microscopy applications. Through personal training and assistance, we support users in performing professional bioimaging efficiently.

Read more.

Umeå Centre for Electron Microscopy (MIMS)

UCEM provides instruments and methods in Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) as a national research infrastructure. UCEM is an interdisciplinary multifunctional core facility for advanced electron microscopy (EM). The SEMs , Merlin and Evo, offer high-resolution surface imaging. With a great configuration of multiple detector systems operating under cryo, room temperature or heated conditions. Correlative Light and Electron Microscopy (CLEM) targeted Shuttle & Find provides a solution for finding the precise location of a target proteins or labeled structure of interest in a large area, simplifying high-precision localization and high-resolution imaging of the same sample.

Read more.

Metabolomics

Metabolomics/lipidomics/fluxomics Unit (FIMM)

FIMM Metabolomics/Lipidomics/Fluxomics Unit, a core service facility, is one of the Biocentre Finland and HiLIFE funded national infrastructure networks. Our technology platform offers services to researchers in many diverse scientific fields. Our core facility provides high-throughput mass spectrometry based targeted quantitative and global metabolomics/lipidomics and fluxomics services to basic, biomedical, preclinical and clinical researchers. 

Read more.

NMR Core Facility at Umeå University (MIMS)

The KBC Core Facility for NMR provides access to state-of-the-art NMR equipment and expertise. Besides studies of soluble proteins and other biomolecules at 850 and 600 MHz, this infrastructure offers nationwide also unique solid-state NMR equipment at 850 and 500 MHz for studies of membrane proteins & amyloid fibrils, metabolomics on intact tissues, environmental NMR and fragment-based screening and is a national support for the Chemical Biological Consortium Sweden (CBCS). High-field instruments are equipped for biomolecular solution NMR, robotic sample preparation and high-throughput metabolomics of biofluids and even intact specimen.

Read more. 

Model organisms

Zebrafish Facility (NCMM)

The zebrafish facility offers access to fish housing and breeding, as well as the use of several instruments for specific research on zebrafish. There are tanks for keeping zebrafish, and separate tanks for generating/regenerating fish lines. The facility also has tanks for breeding and three iSPAWN for large-scale production of synchronized eggs.

Read more. 

Sample preparation and storage

HIPrep Core (FIMM)

HiPrep core is a new service unit of the FIMM Technology Centre. It offers RNA isolation or preparation services for both academic and industry customers. HiPrep core develops workflows for preparation of high-quality nucleic acids from various biological samples in close collaboration with the FIMM sequencing and single cell analytics units and the EV Core.

Read more

Sample Storage (FIMM)

FIMM Sample Storage provides low-cost, secure and controlled storage of samples in liquid nitrogen vapor phase (-190°C). At the moment the system has the capacity to store over 1,4 million sample vials. Another option for storing e.g. serum, plasma and DNA samples in -20°C or -80°C is an automated sample storage and retrieval system. Sample storage service is available to all research groups on the campus and elsewhere for storing small and medium sized sample collections.

Learn more.

Biobank at FIMM
Sample storage at FIMM
Facilities at MIMS
Core facilities at MIMS