Publications

Recent research news on Artificial Biology

19 March 2025 - Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

12 March 2025 - Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

25 February 2025 - Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

14 February 2025 - Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

16 December 2024 - Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Van Vaerenbergh, M., Cardoen, D., M. Formesyn, E., Brunain, M., Van Driessche, G., Blank, S., Spillner, E., Verleyen, P., Wenseleers, T., Schoofs, L., Devreese, B. & C. de Graaf, D. (2013). Extending the honeybee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5. Insect Molecular Biology, 22(2), 199-210.

Song, S., Cheong, L.-Z., Falkeborg, M., Liu, L., Dong, M., Jensen, H. M., Bertelsen, K., Thorsen, M., Tan, T., Xu, X. & Guo, Z. (2013). Facile synthesis of phosphatidyl saccharides for preparation of anionic nanoliposomes with enhanced stability. PLoS One, 8(9), e73891. https://doi.org/10.1371/journal.pone.0073891

Jiang, Z., Xia, D., Li, Y., Li, J., Li, Q., Chen, M., Huang, Y., Besenbacher, F. & Dong, M. (2013). Facilitating the mechanical properties of a high-performance pH-sensitive membrane by cross-linking graphene oxide and polyacrylic acid. Nanotechnology, 24(33), 335704. https://doi.org/10.1088/0957-4484/24/33/335704

Nielsen, K. H. (2013). Fem (gode) grunde til at formidle videnskab. Videnskab.dk. http://videnskab.dk/blog/fem-gode-grunde-til-formidle-videnskab

Otzen, D. & Andersen, K. K. (2013). Folding of outer membrane proteins. Archives of Biochemistry and Biophysics, 531(1-2), 34-43. https://doi.org/10.1016/j.abb.2012.10.008

Klærke, B., Toker, J., Rahbek, D. B., Hornekær, L. & Andersen, L. H. (2013). Formation and stability of hydrogenated PAHs in gas-phase. Astronomy & Astrophysics (A&A), 549, A84. https://doi.org/10.1051/0004-6361/201219952

Abelein, A., Kaspersen, J. D., Nielsen, S. B., Jensen, G. V., Christiansen, G., Pedersen, J. S., Danielsson, J. A., Otzen, D. & Gräslund, A. (2013). Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates. Journal of Biological Chemistry, 288, 23518-23528. https://doi.org/10.1074/jbc.M113.470450

Chen, M., Hein, S., Le, D. Q. S., Feng, W., Foss, M., Kjems, J., Besenbacher, F., Zou, X. & Bünger, C. (2013). Free radicals generated by tantalum implants antagonize the cytotoxic effect of doxorubicin. International Journal of Pharmaceutics, 448(1), 214-20. https://doi.org/10.1016/j.ijpharm.2013.03.041

Simonsen, M., Christensen, M. H., Thomsen, R. & Pedersen, C. N. S. (2013). GPU-Accelerated High-Accuracy Molecular Docking using Guided Differential Evolution. In S. tsutsui & P. Collet (Eds.), Massively Parallel Evolutionary Computation on GPGPUs Springer Publishing Company.

Prado-Martinez, J., Sudmant, P. H., Kidd, J. M., Li, H., Kelley, J. L., Lorente-Galdos, B., Veeramah, K. R., Woerner, A. E., O'Connor, T. D., Santpere, G., Cagan, A., Theunert, C., Casals, F., Laayouni, H., Munch, K., Hobolth, A., Halager, A. E., Malig, M., Hernandez-Rodriguez, J. ... Marques-Bonet, T. (2013). Great ape genetic diversity and population history. Nature, 499, 471–475. https://doi.org/10.1038/nature12228

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Revised 03.03.2026