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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Basaiawmoit, R. V., Deva, T., Runager, K., Kristensen, T., Enghild, J. J. & Otzen, D. (2009). The Underlying Mechanisms of TGFBIp-mediated Corneal Dystrophies. Abstract from Asia ARVO, International Meeting on Research in Vision and Ophthalmology, Hyderabad International Convention Center. Abstract number: PAP05.01, Hyderabad, India.

Nielsen, K. H. (2009). Tilfældets lovmæssighed. Videnskab.dk.

Baouche, S., Hornekær, L., Baurichter, A., Luntz, A. C., Petrunin, V. V. & Sljivancanin, Z. (2009). Translational energy and state resolved observations of D and D₂ thermallydesorbing from D clusters chemisorbed on graphite. Journal of Chemical Physics, 131, 244707.

Li, Y., Li, Y., Yao, Y., Liu, B., Chen, M., Song, X. & Dong, M. (2009). Two-dimensional scaffold layer formations on a solid surface through xanthan polysaccharide: temperature effect. Colloids and Surfaces B: Biointerfaces, 74(1), 136-9. https://doi.org/10.1016/j.colsurfb.2009.07.007

Chen, M., Yanqing Li, Yinli Li, Yuhen Yao, Bo Liu & Xiangzhi Song and Mingdong Dong (2009). Two-dimensional scaffold layer formations on a solid surface through xanthan polysaccharide: Temperature effect. Colloids and Surfaces B: Biointerfaces, 74(1).

Nielsen, J. T., Bjerring, M., Jeppesen, M., Pedersen, R. O., Pedersen, J. M., Hein, K. L., Vosegaard, T., Skrydstrup, T., Otzen, D. & Nielsen, N. C. (2009). Unique Identification of Supramolecular Structures in Amyloid Fibrils by Solid-State NMR. Poster session presented at 50th Experimental NMR conference (ENC), Asilomar, CA, United States.

Nielsen, J. T., Bjerring, M., Jeppesen, M., Pedersen, R. O., Pedersen, J. M., Hein, K. L., Vosegaard, T., Skrydstrup, T., Otzen, D. & Nielsen, N. C. (2009). Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy. Angewandte Chemie International Edition, 48, 2118-2121.

Malmos, K., Dong, M., Pillai, S., Kingshott, P., Besenbacher, F., Pedersen, S. U. & Daasbjerg, K. (2009). Using a hydrazone-protected benzenediazonium salt to introduce a near-monolayer of benzaldehyde on glassy carbon surfaces. Journal of the American Chemical Society, 131(13), 4928-36. https://doi.org/10.1021/ja809816x

Jensen, P. L., Dueholm, M. S., Larsen, P., Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H. & Otzen, D. (2009). Widespread abundance of Functional Bacterial Amyloid in Mycolata and other Gram positive Bacteria. Applied and Environmental Microbiology, 75, 4101-4110.

Otzen, D., Sehgal, P. & Westh, P. (2009). α-lactalbumin is unfolded by all classes of detergents but with different mechanisms. Journal of Colloid and Interface Science, 329, 273-283.

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Kalinka Hansen