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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Pedersen, J. N., Frislev, H. K. S., Pedersen, J. S. & Otzen, D. E. (2016). Using protein-fatty acid complexes to improve vitamin D stability. Journal of Dairy Science, 99(10), 7755–7767. https://doi.org/10.3168/jds.2016-11343

Sehgal, P., Mogensen, J. E. & Otzen, D. (2005). Using micellar mole fractions to assess membrane protein stability in mixed micelles. Biochimica et Biophysica Acta - Biomembranes, 1761, 59-68. https://doi.org/10.1016/j.bbamem.2005.08.006

Frislev, H. S., Nielsen, J., Nylandsted, J. & Otzen, D. (2018). Using Liprotides to Deliver Cholesterol to the Plasma Membrane. Journal of Membrane Biology, 25(4), 581-592. https://doi.org/10.1007/s00232-018-0034-y

Larsen, C. K., Lindquist, P., Rosenkilde, M., Madsen, A. R., Haselmann, K., Glendorf, T., Olesen, K., Kodal, A. L. B. & Tørring, T. (2024). Using LanM Enzymes to Modify Glucagon-Like Peptides 1 and 2 in E. coli. ChemBioChem, 25(13), Article e202400201. https://doi.org/10.1002/cbic.202400201

Kristensen, T. G., Nielsen, J. & Pedersen, C. N. S. (2011). Using Inverted Indices for Accelerating LINGO Calculations. Journal of Chemical Information and Modeling, 51(3), 597-600. https://doi.org/10.1021/ci100437e

Ebbesen, M. & Pedersen, B. D. (2007). Using Empirical Ethics to Formulate Normative Ethical Principles in Biomedicine. Medicine, Health Care and Philosophy, (1), 33-48.

Malmos, K., Dong, M., Pillai, S., Kingshott, P., Besenbacher, F., Pedersen, S. U. & Daasbjerg, K. (2009). Using a hydrazone-protected benzenediazonium salt to introduce a near-monolayer of benzaldehyde on glassy carbon surfaces. Journal of the American Chemical Society, 131(13), 4928-36. https://doi.org/10.1021/ja809816x

Nielsen, K. H. (2023). USAs skæbneår. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2024). Uro i sindet. Weekendavisen, Sektion 4 (Ideer), 5.

Bregnhøj, M., Dichmann, L., McLoughlin, C. K., Westberg, M. & Ogilby, P. R. (2019). Uric Acid: A Less-than-Perfect Probe for Singlet Oxygen. Photochemistry and Photobiology, 95(1), 202-210. https://doi.org/10.1111/php.12971

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Kalinka Hansen