AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Song, J., Arbona, J.-M., Zhang, Z., Liu, L., Xie, E., Elezgaray, J., Aime, J.-P., Gothelf, K. V., Besenbacher, F. & Dong, M. (2012). Direct visualization of transient thermal response of a DNA origami. Journal of the American Chemical Society, 134(24), 9844-9847. https://doi.org/10.1021/ja3017939
Kötzler, M. P., Blank, S., Bantleon, F. I., Spillner, E. & Meyer, B. (2012). Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8). B B A - General Subjects, 1820(12), 1915-1925. https://doi.org/10.1016/j.bbagen.2012.08.018
Schiølin, K. H. (2012). Dronekrigeren og krigen på skærmen. Slagmark: tidsskrift for idéhistorie , 63, 79-92.
Juul, S., Nielsen, C. J. F., Labouriau, R., Roy, A., Tesauro, C., Jensen, P. W., Harmsen, C., Kristoffersen, E. L., Chiu, Y.-L., Hougaard, R. F., Fiorani, P., Cox-Singh, J., Tordrup, D. P., Koch, J. E., Bienvenu, A.-L., Desideri, A., Picot, S., Petersen, E., Leong, K. W. ... Knudsen, B. R. (2012). Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement. A C S Nano, 6(12), 10676-10683. https://doi.org/10.1021/nn3038594
Schlafer, S., Meyer, R. L., Sutherland, D. S. & Stadler, B. M. (2012). Effect of Osteopontin on the Initial Adhesion of Dental Bacteria. Journal of Natural Products, 75(12), 2108-2012. https://doi.org/10.1021/np300514z
Gupta, V., Markmann, K., Pedersen, C. N. S., Stougaard, J. & Andersen, S. U. (2012). shortran: A pipeline for small RNA-seq data analysis. Bioinformatics, 28(20), 2698-2700. https://doi.org/10.1093/bioinformatics/bts496
Fejerskov, B., Jensen, B. E. B., Jensen, N. B. S., Chong, S. F. & Zelikin, A. N. (2012). Engineering surface adhered poly(vinyl alcohol) physical hydrogels as enzymatic microreactors. A C S Applied Materials and Interfaces, 4(9), 4981-90. https://doi.org/10.1021/am3013467
Song, J., Kahveci, D., Chen, M., Guo, Z., Xie, E., Xu, X., Besenbacher, F. & Dong, M. (2012). Enhanced Catalytic Activity of Lipase Encapsulated in PCL Nanofibers. Langmuir, 28. https://doi.org/10.1021/la300469s
Han, Q., Yang, R., Li, J., Liang, W., Zhang, Y., Wang, C., Dong, M. & Besenbacher, F. (2012). Enhancement of biological activities of nanostructured hydrophobic drug species. Nanoscale, 4(6), 2078-82. https://doi.org/10.1039/c2nr12013e
Finster, K., Temkiv, T. S. & Kjeldsen, H. (2012). Er der liv derude? Aktuel Naturvidenskab, (6), 22-25.

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Revised 03.03.2026
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Kalinka Hansen