AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Li, S., Zhu, T., Dong, L. & Dong, M. (2018). Boosted visible light photodegradation activity of boron doped rGO/g-C3N4 nanocomposites: the role of C-O-C bonds. New Journal of Chemistry, 42(21), 17644-17651. https://doi.org/10.1039/c8nj03571g
Gao, S., Hu, X., Xu, F., Gao, C., Xiong, K., Zhao, X., Chen, H., Zhao, S., Wang, M., Fu, D., Zhao, X., Bai, J., Mao, L., Li, B., Wu, S., Wang, J., Li, S., Yang, H., Bolund, L. & Pedersen, C. N. S. (2018). BS-virus-finder: virus integration calling using bisulfite sequencing data. GigaScience, 7(1), 1-7. https://doi.org/10.1093/gigascience/gix123
Song, W., Yang, C., Svend Le, D. Q., Zhang, Y. & Kjems, J. (2018). Calcium-microRNA Complexes Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells. A C S Applied Materials and Interfaces, 10(9), 7756-7764. https://doi.org/10.1021/acsami.7b18289
Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, J. R. & Otzen, D. E. (2018). Can a Charged Surfactant Unfold an Uncharged Protein? Biophysical Journal, 115(11), 2081-2086. https://doi.org/10.1016/j.bpj.2018.10.022
Nielsen, K. H. (2018). Cannabis. Weekendavisen, Sektion 4 (Ideer), 10.
Wang, Y., Xia, Q., Bai, X., Ge, Z., Yang, Q., Yin, C., Kang, S., Dong, M. & Li, X. (2018). Carbothermal activation synthesis of 3D porous g-C3N4/carbon nanosheets composite with superior performance for CO2 photoreduction. Applied Catalysis B: Environment and Energy, 239, 196-203. https://doi.org/10.1016/j.apcatb.2018.08.018
Vu Quang, H., Chang, C.-C., Song, P., Hauge, E. M. & Kjems, J. (2018). Caveolae-mediated mesenchymal stem cell labelling by PSS-coated PLGA PFOB nano-contrast agent for MRI. Theranostics, 8(10), 2657-2671. https://doi.org/10.7150/thno.23206
Larsen, M. T., Rawsthorne, H., Schelde, K. K., Dagnæs-Hansen, F., Cameron, J. & Howard, K. (2018). Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement. Journal of Controlled Release, 287, 132-141. https://doi.org/10.1016/j.jconrel.2018.07.023
Russkamp, D., Van Vaerenbergh, M., Etzold, S., Eberlein, B., Darsow, U., Schiener, M., De Smet, L., Absmaier, M., Biedermann, T., Spillner, E., Ollert, M., Jakob, T., Schmidt-Weber, C. B., de Graaf, D. C. & Blank, S. (2018). Characterization of the honeybee venom proteins C1q-like protein and PVF1 and their allergenic potential. Toxicon, 150, 198-206. https://doi.org/10.1016/j.toxicon.2018.05.017
Kristensen, L. S., Okholm, T. L. H., Venø, M. T. & Kjems, J. (2018). Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biology, 15(2), 280-291. https://doi.org/10.1080/15476286.2017.1409931

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Revised 03.03.2026
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Kalinka Hansen