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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Jiang, A., Chen, C., Feng, J., Li, Q., Liu, W. & Dong, M. (2025). Boosting electrocatalytic hydrogen evolution via partial oxidation of rhenium through cobalt modification in nanoalloy structure. Journal of Colloid and Interface Science, 677(Part B), 617-625. https://doi.org/10.1016/j.jcis.2024.08.084
Teixeira, L. M. C., Paiva, P., Ferreira, P., Rotilio, L., Morth, J. P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Bridging experiment and theory: a computational exploration of UMG-SP3 dynamics. Pure and Applied Chemistry, 97(10), 1405-1418. https://doi.org/10.1515/pac-2025-0489
García-Rodríguez, J. L., Korsgaard, U., Vissing, S. M., Paasch, T. P., Semenova, M., Vendelbo, S. L., Jensby, E. F., Williams, H. L., Salachan, P. V., Brandt, C. B., Hanimann, J., Lin, L., Zlobec, I., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2025). Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer. Communications Biology, 8(1), Article 1345. https://doi.org/10.1038/s42003-025-08799-x
Langmüller, A. M., Hermisson, J., Murdock, C. & Messer, P. W. (2025). Catching a wave: On the suitability of traveling-wave solutions in epidemiological modeling. Theoretical Population Biology, 162, 1-12. https://doi.org/10.1016/j.tpb.2024.12.004
De Dios Andres, P., Pendlmayr, S., Gal, N., Abild Meyer, C., Ryberg, C., Vestrheim, O., Kalacas, N. A., Demir, F., Rinschen, M. M., Haupt, K., Mookerjee, R. P. & Städler, B. (2025). Cell Membrane Vesicle Camouflaged Artificial Cells. Advanced Functional Materials, 35(30), Article 2424504. https://doi.org/10.1002/adfm.202424504
Paasch, T. P., Olesen, M. T. J., García-Rodríguez, J. L., Assmus, A. M., Fenton, R. A., Kjems, J., Hager, H. & Kristensen, L. S. (2025). ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. PLoS Genetics, 21(6), Article e1011726. https://doi.org/10.1371/journal.pgen.1011726
Slumstrup, L., Thrower, J. D., Hopkinson, A. T., Wenzel, G., Jaganathan, R., Schrauwen, J. G. M., Redlich, B., Ioppolo, S. & Hornekær, L. (2025). CO desorption from interstellar icy grains induced by infrared excitation of superhydrogenated polycyclic aromatic hydrocarbons. Astronomy and Astrophysics, 704, Article A74. https://doi.org/10.1051/0004-6361/202556399
Slumstrup, L., Thrower, J. D., Hopkinson, A. T., Wenzel, G., Jaganathan, R., Schrauwen, J. G. M., Redlich, B., Ioppolo, S. & Hornekær, L. (2025). CO desorption from interstellar icy grains induced by IR excitation of superhydrogenated PAHs.
Bendtsen, M. K., Nowak, J. S., Paiva, P., López Hernández, M., Ferreira, P., Pedersen, J. S., Bekker, N. S., Viezzi, E., Bisiak, F., Brodersen, D. E., Pedersen, L. H., Zervas, A., Fernandes, P. A., Ramos, M. J., Stougaard, P., Thøgersen, M. S. & Otzen, D. E. (2025). Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca2+ Ions and Conformational Dynamics in Psychrophilicity. Biomolecules, 15(3), Article 415. https://doi.org/10.3390/biom15030415
Fage-Butler, A., Nielsen, K. H. & Ledderer, L. K. (2025). Conclusion. In Science communication and trust (pp. 493-509). Palgrave Macmillan. https://doi.org/10.1007/978-981-96-1289-5_24

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Kalinka Hansen