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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Wu, X., Xia, D., Shi, T., Li, B., Wang, D., Liang, C. & Dong, M. (2025). Thermo-responsive microneedles patch for transdermal drug delivery via squeezing in diabetic foot ulcers. Journal of Materials Science and Technology, 205, 299-314. https://doi.org/10.1016/j.jmst.2024.03.068
O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x
Brito, L. F., Friis, M. K., Zhu, H., Brautaset, T., Wendisch, V. F. & Irla, M. K. (2025). Tools and Strategies for Engineering Bacillus methanolicus: A Versatile Thermophilic Platform for Sustainable Bioproduction from Methanol and Alternative Feedstocks. Synthetic Biology and Engineering, 3(4). https://doi.org/10.70322/sbe.2025.10016
Paiva, P., Teixeira, L. M. C., Ferreira, P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Transforming Computational Power into Environmental Solutions: HPC-driven Research on Urethanase-mediated Plastic Degradation. Procedia Computer Science, 267, 207-217. https://doi.org/10.1016/j.procs.2025.08.247
Andersen, D. G., Pedersen, A. B., Montasell, M. C., Moesgaard, S., Bohn, A. B. & Zelikin, A. N. (2025). Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes. Advanced Functional Materials, 35(34), Article 2503381. https://doi.org/10.1002/adfm.202503381
Bregnhøj, M., Wili, N., Nielsen, A. B., Jensen, S. J. K., Nørnberg, P., Nielsen, N. C., Skibsted, J. & Finster, K. (2025). Triboelectrically Mediated Surface Reduction of Quartz Sand by Tumbling in Hydrogen Gas. Journal of Physical Chemistry C, 129(24), 10900-10910. https://doi.org/10.1021/acs.jpcc.5c02082
Nielsen, K. H. (2025). Trump og atomet. Weekendavisen, Sektion 4 (Ideer), 5.
Li, T. H., Ma, L., Wang, L., Wang, H. B., Li, B., Han, M. Y., Li, D. F., Bai, C. G., Dong, M. D., Shen, L. H., Ma, S. & Qi, F. (2025). Ultra-wide band electromagnetic wave absorption by decorating the magnetic particles on two-dimensional Ti3C2Tx. Rare Metals, 44(3), 1844-1855. Article 204105. https://doi.org/10.1007/s12598-024-03170-1
Chang, Y., Cheng, Y., Jia, R., Wang, R., Xu, Q., Gong, L., Wei, Y., Tang, B., Guo, C., Sun, B., He, X., Li, X., Gong, L., Ye, H., Wang, X., Dai, Y., Dong, M., Tang, Y., Zhang, F. ... Pan, T. (2025). Unified iontronic sensing for operando monitoring of physical-chemical events in lithium-ion batteries. National Science Review, 12(6), Article nwaf151. https://doi.org/10.1093/nsr/nwaf151
Paiva, P., Teixeira, L. M. C., Wei, R., Liu, W., Weber, G., Morth, J. P., Westh, P., Petersen, A. R., Johansen, M. B., Sommerfeldt, A., Sandahl, A., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Unveiling the enzymatic pathway of UMG-SP2 urethanase: insights into polyurethane degradation at the atomic level. Chemical Science, 16(5), 2437-2452. https://doi.org/10.1039/d4sc06688j

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Kalinka Hansen