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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Andreis, L., Bassetti, F. & Hirsch, C. (2026). LDP for the covariance process in fully connected Gaussian neural networks. Electronic Journal of Probability, 31, Article 22. https://doi.org/10.1214/26-EJP1477
Pendlmayr, S., Ryberg, C., Ramos-Docampo, M. A., Wilkens Juhl, D., Nielsen, N. C., Burdick, J. A. & Städler, B. (2026). Light-responsive 3D printed fish-shaped actuator based on granular hydrogel inks. Materials Today Chemistry, 52, Article 103364. https://doi.org/10.1016/j.mtchem.2026.103364
Hirsch, C. & Owada, T. (2026). Limit theorems under heavy-tailed scenario in the age-dependent random connection models. Stochastic Processes and Their Applications, 192, Article 104815. https://doi.org/10.1016/j.spa.2025.104815
Neis, K., Civit Pitarch, L., Pedersen, K., Schachtner, M., Wengel, J., Wagner, R., Thiel, S., Kjems, J. & Valero Moreno, J. (2026). Lock, Protect, and Bind: In Vitro Selection of Locked Nucleic Acid-Modified Aptamers Using a Mutant T7 RNA Polymerase. Small Structures, 7(3), Article e202500677. https://doi.org/10.1002/sstr.202500677
Li, B., Dong, M. & Li, Q. (2026). Macroscale superlubricity under high pressure enabled by partially oxidized MXene nanosheets. Materials Today Nano, 33, Article 100748. https://doi.org/10.1016/j.mtnano.2025.100748
Wang, A. G., Wu, W. M., Dong, M. D., Ji, M., Yu, Z. Q., Liang, Y. X. & Xu, M. Y. (2026). Making waves: Harnessing electroactive microorganisms for efficient and sustainable removal of emerging contaminants in wastewater treatment plants. Water Research, 289, Article 124900. https://doi.org/10.1016/j.watres.2025.124900
Nielsen, K. H. (2026). Markovnikovs regel. Weekendavisen, Sektion 4 (Ideer), 5.
Adam, L., Molenkamp, W. H., Nowak, J. S., Farzadfard, A., Gaarthuis, K., Kumar, R., Nielsen, J., Otzen, D. E., Johansson, J. & Abelein, A. (2026). Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain. The Journal of Biological Chemistry, 302(6), 113117. Advance online publication. https://doi.org/10.1016/j.jbc.2026.113117
Zhang, Y., Zhao, F., Chen, S., Li, B., Dong, J., Chen, Y., Liu, Y., Qiao, A. & Chen, M. (2026). Melt electrowriting-enabled hybrid platforms: Toward functional biomimetic scaffolds for cellular interaction and tissue regeneration. Acta Biomaterialia, 213, 21-61. https://doi.org/10.1016/j.actbio.2026.02.015
Kromm, F. E. H., Møller, S. L. B., Jensen, A. S., Wørmer, G. J., Rasmussen, M. H., B. Svenningsen, E., Tørring, T. & Poulsen, T. B. (2026). Modular Total Synthesis of Lasalocid Acid A through Direct C(sp3)–C(sp3) Attached Ring Construction. Journal of the American Chemical Society, 148(1), 249-257. https://doi.org/10.1021/jacs.5c11543

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Revised 03.03.2026
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Kalinka Hansen