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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Nielsen, K. H. (2025). Højt at flyve. Weekendavisen, Sektion 4 (Ideer), 5.
Nielsen, K. H. (2025). Hvem opdagede malariamyggen? Weekendavisen, Sektion 4 (Ideer), 5.
Teixeira, L. M. C., Paiva, P., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Rotilio, L., Sandahl, A., Morth, J. P., Westh, P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Hydrolysis of the Urethane Bond Catalyzed by Pseudomonas sp. MIS38 Lipase: A QM/MM Mechanistic Insight. ACS Catalysis, 15, 14728-14740. https://doi.org/10.1021/acscatal.5c03228
Nielsen, K. H. (2025). I Darwins navn. Weekendavisen, Sektion 4 (Ideer), 5.
Brito, L. F., Luciano, D., Irla, M., Virant, D., Courtade, G. & Brautaset, T. (2025). Identification of MscS as a Key L-Glutamate Exporter in Bacillus methanolicus. Microbial Biotechnology, 18(10), Article e70252. https://doi.org/10.1111/1751-7915.70252
Gothelf, K. V., Kjems, J., Otzen, D. E., Nielsen, N. C., Hornekær, L., Zelikin, A., Pedersen, J. S., Vorup-Jensen, T. & Sutherland, D. S. (2025). Ingen reel mulighed for medarbejdere for at gøre indsigelse mod ledelsens beslutning om at afvikle iNANO. Omnibus, 2025(Juni). https://omnibus.au.dk/arkiv/vis/artikel/aabent-brev-medarbejdere-er-sat-uden-for-indflydelse-i-ledelsens-beslutning-om-at-afvikle-inano
Huertas-Díaz, L., Vestergaard, L. G., Marietou, A., Irla, M., Behr, J., Somoza, M. M., Feilberg, A. & Schwab, C. (2025). Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens. Gut Pathogens, 17(1), Article 23. https://doi.org/10.1186/s13099-025-00689-1
Otzen, D. E., Peña-Díaz, S., Widmann, J., Daugberg, A. O. H., Zhang, Z., Jiang, Y., Mittal, C., Dueholm, M. K. D., Louros, N., Wang, H. & Javed, I. (2025). Interactions between pathological and functional amyloid: A match made in Heaven or Hell? Molecular Aspects of Medicine, 103, 101351. Article 101351. https://doi.org/10.1016/j.mam.2025.101351
Fage-Butler, A., Ledderer, L. & Nielsen, K. H. (2025). Introduction. In Science Communication and Trust (pp. 1-21). Springer. https://doi.org/10.1007/978-981-96-1289-5_1
Olsen, W. P., Larsen, A.-K. K., Christensen, J. L., Malle, M. G. & Otzen, D. E. (2025). Investigating strategies for creating cross-linked amyloid fibril networks through branching of amyloid growth. Colloids and Surfaces B: Biointerfaces, 251, 114617. Article 114617. https://doi.org/10.1016/j.colsurfb.2025.114617

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Revised 03.03.2026
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Kalinka Hansen