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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Monti, M., Milanetti, E., Frans, M. T., Miotto, M., Di Rienzo, L., Baranov, M. V., Gosti, G., Somavarapu, A. K., Nagaraj, M., Golbek, T. W., Rossing, E., Moons, S. J., Boltje, T. J., van den Bogaart, G., Weidner, T., Otzen, D. E., Tartaglia, G. G., Ruocco, G. & Roeters, S. J. (2024). Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain. The journal of physical chemistry. B, 128(2), 451-464. https://doi.org/10.1021/acs.jpcb.3c06258
Jørgensen, A. G., Dupont, D. M., Fjelstrup, S., Bus, C., Hansen, C. B., Benfield, T., Garred, P., Heegaard, P. M. H. & Kjems, J. (2024). Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk factors. Molecular Therapy Nucleic Acids, 35(3), Article 102253. https://doi.org/10.1016/j.omtn.2024.102253
Nielsen, K. H. & Andersen, C. (2024). UNESCO as a teacher of norms in science popularization: Science dissemination, cultural diplomacy and global-norm-setting 1945-1955. 318. Abstract from Science, Technology, Humanity, and the Earth, Barcelona, Spain. https://docs.google.com/document/d/1aUPITTDo6aFtpYL-Mah2XZzarAGgVXzh/edit
Nielsen, K. H. (2024). Uro i sindet. Weekendavisen, Sektion 4 (Ideer), 5.
Larsen, C. K., Lindquist, P., Rosenkilde, M., Madsen, A. R., Haselmann, K., Glendorf, T., Olesen, K., Kodal, A. L. B. & Tørring, T. (2024). Using LanM Enzymes to Modify Glucagon-Like Peptides 1 and 2 in E. coli. ChemBioChem, 25(13), Article e202400201. https://doi.org/10.1002/cbic.202400201
Nielsen, K. H. (2024). Videnskab i blåzonen. Weekendavisen, Sektion 4 (Ideer), 5.
Eriksen, C. B. & Ploug, I. K., (Trans.) (2024). Videnskabshistoriens fremtid: En samtale med Lorraine Daston. Slagmark: tidsskrift for idéhistorie , 87, 125-142.
Nielsen, K. H. (2024). Vinderen tager det hele. Weekendavisen, Sektion 4 (Ideer), 11. https://www.weekendavisen.dk/ideer/vinderen-tager-det-hele
Nielsen, L. S., Šantl-Temkiv, T., Palomeque Sánchez, M., Massling, A., Ward, J. C., Jensen, P. B., Boesen, T., Petters, M., Finster, K., Bilde, M. & Rosati, B. (2024). Water Uptake of Airborne Cells of P. syringae Measured with a Hygroscopicity Tandem Differential Mobility Analyzer. Environmental Science & Technology, 58(43), 19211-19221. https://doi.org/10.1021/acs.est.4c01817
Bian, T., Pei, Y., Gao, S., Zhou, S., Sun, X., Dong, M. & Song, J. (2024). Xeno Nucleic Acids as Functional Materials: From Biophysical Properties to Application. Advanced Healthcare Materials, 13(28), Article 2401207. https://doi.org/10.1002/adhm.202401207

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Revised 03.03.2026
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Kalinka Hansen