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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2026). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, 15(10), Article e03932. https://doi.org/10.1002/adhm.202503932
Nielsen, K. H. & Christensen, E. R. (2026). Communicating dual-use quantum technologies across science, politics, the military, and business. EPJ Quantum Technology. Advance online publication. https://doi.org/10.1140/epjqt/s40507-026-00533-8
Zhang, Z., Liu, Q., Zhu, S., Ye, M., Dong, M. & Xu, R. X. (2026). Construction of Perfusable Microvascular Networks via Peptide Self-Assembly toward AI-Assisted Biomedical Engineering Applications. In Proceedings of 2026 2nd International Conference on Artificial Intelligence and Materials, ICAIM 2026 IEEE. https://doi.org/10.1109/ICAIM69488.2026.11601865
Li, L., Li, F., Cui, M., Liu, L., Zhen, X., Wei, J., Cui, J., Dong, J., Long, J., Dong, M. & Wang, X. (2026). Controlling Cleavage of Cα–CβBonds in Lignin Induced by Photo-Driven Iron Salt at Simulated Natural Environment Conditions. ACS Catalysis, 16(5), 4712-4728. https://doi.org/10.1021/acscatal.5c08182
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2026). Corrigendum to “The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier” [Int. J. Biol. Macromol. Volume 290 (2025), 140387] (S0141813025009365), (10.1016/j.ijbiomac.2025.140387). International Journal of Biological Macromolecules, 337, Article 149909. https://doi.org/10.1016/j.ijbiomac.2025.149909
Khider, M. L. K., Irla, M., López, M. G., Gispert, A., Konjetzko, T., Meliawati, M., Schmid, J., Brautaset, T. & Brito, L. F. (2026). CRISPR-Cas9-driven genome editing in Bacillus methanolicus MGA3. Frontiers in Microbiology, 16, Article 1728984. https://doi.org/10.3389/fmicb.2025.1728984
Jensen, R. K., Miehe, M., Gandini, R., Jørgensen, M. H., Spillner, E. & Andersen, G. R. (2026). Cryo-EM Structure of FcεRI Bound IgE Reveals Multiple Defined Conformations of the Fab-Fc Hinge. Allergy: European Journal of Allergy and Clinical Immunology, 81(6), 2047-2058. https://doi.org/10.1111/all.70132
Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158
Nielsen, K. H. (2026). Darwins misundelige rival. Weekendavisen, Sektion 4 (Ideer), 13.
Nielsen, K. H. (2026). Det fælles vi. Weekendavisen, Sektion 4 (Ideer), 5.

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Revised 03.03.2026
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Kalinka Hansen