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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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De Putte, D. V., Meshaka, R., Trahin, B., Habart, E., Peeters, E., Berné, O., Alarcón, F., Canin, A., Chown, R., Schroetter, I., Sidhu, A., Boersma, C., Bron, E., Dartois, E., Goicoechea, J. R., Gordon, K. D., Onaka, T., Tielens, A. G. G. M., Verstraete, L. ... Zhen, J. (2024). PDRs4All VIII. Mid-infrared emission line inventory of the Orion Bar. Astronomy and Astrophysics, 687, Article A86. https://doi.org/10.1051/0004-6361/202449295
Eriksen, C. B. (2024). Peering Horizontally Through the Microscope: Stephen Gaukroger Explains the Middling World. In C. Wolfe & A. Waldow (Eds.), Science and the Shaping of Modernity: Essays in Honor of Stephen Gaukroger (pp. 113-121). Springer. https://doi.org/10.1007/978-3-031-76037-2_12
Hobolth, A., Rivas-González, I., Bladt, M. & Futschik, A. (2024). Phase-type distributions in mathematical population genetics: An emerging framework. Theoretical Population Biology, 157, 14-32. https://doi.org/10.1016/j.tpb.2024.03.001
Zhang, Y., Su, H., Wang, W., Dong, M. & Han, X. (2024). Phospholipid Epitaxial Assembly Behavior on a Hydrophobic Highly Ordered Pyrolytic Graphite Surface. Langmuir, 40(2), 1439-1446. https://doi.org/10.1021/acs.langmuir.3c03145
Teodori, L., Kroer, S., Omer, M., Andersen, V. L., Bech, P., Su, J., Bridoux, J., Nielsen, J. S., Bertelsen, M. B., Hernot, S., Gothelf, K. V. & Kjems, J. (2024). Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging. Molecular Therapy - Nucleic Acids, 35(3), Article 102305. https://doi.org/10.1016/j.omtn.2024.102305
Brodszkij, E., Ryberg, C., Lyons, J. A., Juhl, D. W., Nielsen, N. C., Sigalas, N. I., Lyulin, A. V., Pedersen, J. S. & Städler, B. (2024). Poly(Sitosterol)-Based Hydrophobic Blocks in Amphiphilic Block Copolymers for the Assembly of Hybrid Vesicles. Small, 20(40), Article 2401934. https://doi.org/10.1002/smll.202401934
Greussing, E., Guenther, L., Baram-Tsabari, A., Dabran-Zivan, S., Jonas, E., Klein-Avraham, I., Taddicken, M., Beets, B., Brossard, D., Chakraborty, A., Agergaard, T. E., Fage-Butler, A., Ju Huang, C., Nielsen, K. H., Kankaria, S., Lo, Y.-Y., Riedlinger, M. & Song, H. J. (2024). Predicting and describing the use of generative AI in science-related information search: Insights from a multinational survey. Abstract from Annual Conference of the “Science Communication” Division of the German Communication Association 2024, Zürich, Switzerland. https://www.ikmz.uzh.ch/dam/jcr:f29f21aa-1025-4b39-b848-4aefbd13a781/AI&SCICOMM24_Book%20of%20Abstracts.pdf
Nielsen, K. H. (2024). Problemet med Central Park. Weekendavisen, Sektion 4 (Ideer), 5.
Nielsen, K. H. (2024). Professorens prutter. Weekendavisen, Sektion 4 (Ideer), 5.
Malle, M. G., Song, P., Löffler, P. M. G., Kalisi, N., Yan, Y., Valero, J., Vogel, S. & Kjems, J. (2024). Programmable RNA Loading of Extracellular Vesicles with Toehold-Release Purification. Journal of the American Chemical Society, 146(18), 12410-12422. https://doi.org/10.1021/JACS.3C13123

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Kalinka Hansen