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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Nielsen, K. H., Kaarsted, T., Overgaard, A. K., Okholm, A. L. & Martek, A. (2024). Adapting to change: transforming research libraries into catalysts for citizen science in a rapidly evolving world. 74. Abstract from European Citizen Science Association 2024 Conference: Change, Vienna, Austria. https://2024.ecsa.ngo/images/Images/2024/ABSTRACT%2009.pdf
Brodszkij, E. & Städler, B. (2024). Advances in block copolymer-phospholipid hybrid vesicles: from physical-chemical properties to applications. Chemical Science, 15(28), 10724-10744. https://doi.org/10.1039/d4sc01444h
Krissanaprasit, A., Mihalko, E., Meinhold, K., Simpson, A., Sollinger, J., Pandit, S., Dupont, D. M., Kjems, J., Brown, A. C. & LaBean, T. H. (2024). A functional RNA-origami as direct thrombin inhibitor with fast-acting and specific single-molecule reversal agents in vivo model. Molecular Therapy, 32(7), 2286-2298. https://doi.org/10.1016/j.ymthe.2024.05.002
Yuan, L., Li, M., Li, J., Zhu, T. F., Dong, M. & Liu, L. (2024). Aggregation-induced signal amplification strategy based on peptide self-assembly for ultrasensitive electrochemical detection of melanoma biomarker. Analytica Chimica Acta, 1289, Article 342214. https://doi.org/10.1016/j.aca.2024.342214
Fuglsang, S., Fage-Butler, A. & Nielsen, K. H. (2024, Jan 18). AI kan få forskningen ud af elfenbenstårnet – men også misinformere masserne. https://www.altinget.dk/forskning/artikel/forskere-ai-kan-faa-forskningen-ud-af-elfenbenstaarnet-men-ogsaa-misinformere-masserne
Nielsen, K. H. (2024). AMOC-alarm. Weekendavisen, Sektion 4 (Ideer), 5.
Elkhashab, M., Dilek, Y., Foss, M., Creemers, L. B. & Howard, K. A. (2024). A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics: Molecular Pharmaceutics. Molecular Pharmaceutics, 21(2), 491-500. https://doi.org/10.1021/acs.molpharmaceut.3c00561
Civit, L., Moradzadeh, N., Jonczyk, A., Neckermann, P., Asbach, B., Peterhoff, D., Wagner, R., Famulok, M., Mayer, G., Kjems, J. & Valero, J. (2024). A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein. International Journal of Molecular Sciences , 25(9), Article 4642. https://doi.org/10.3390/ijms25094642
Dinesen, A., Andersen, V. L., Elkhashab, M., Pilati, D., Bech, P., Fuchs, E., Samuelsen, T. R., Winther, A., Cai, Y., Märcher, A., Wall, A., Omer, M., Nielsen, J. S., Chudasama, V., Baker, J. R., Gothelf, K. V., Wengel, J., Kjems, J. & Howard, K. A. (2024). An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation. Bioconjugate Chemistry, 35(2), 214-222. https://doi.org/10.1021/acs.bioconjchem.3c00491
Westberg, M., Su, Y., Zou, X., Huang, P., Rustagi, A., Garhyan, J., Patel, P. B., Fernandez, D., Wu, Y., Hao, C., Lo, C. W., Karim, M., Ning, L., Beck, A., Saenkham-Huntsinger, P., Tat, V., Drelich, A., Peng, B. H., Einav, S. ... Lin, M. Z. (2024). An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Science Translational Medicine, 16(738), Article eadi0979. https://doi.org/10.1126/scitranslmed.adi0979

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Revised 03.03.2026
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Kalinka Hansen