AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Nielsen, K. H. (2026). Vidensblokkere. Weekendavisen, Sektion 4 (Ideer), 5.
Nielsen, K. H. (2025). Abernes kulturkrig. Weekendavisen, Sektion 4 (Ideer), 5.
Ramos Docampo, M. A., Abild Meyer, C., Ryberg, C., Otzen, D. E., Hirsch, C. & Städler, B. (2025). Actin Polymerizing Motors to Assist Cytoskeleton-like Networks Formation in Artificial Cells. ACS Nano, 19(42), 37324-37338. https://doi.org/10.1021/acsnano.5c12624
Montasell, M. C., Raeven, L. M. V., Ravn Malm, M., van Hest, J. C. M. & Zelikin, A. N. (2025). Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification. Nature Communications, 16(1), Article 9638. https://doi.org/10.1038/s41467-025-64636-z
Elkhashab, M., Barreto, G., Fauconnier, M., Le Bourlout, Y., Creemers, L. B., Nieminen, H. J. & Howard, K. A. (2025). ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound. Drug Delivery, 32(1), Article 2464921. https://doi.org/10.1080/10717544.2025.2464921
Lund, A., Dorn, B., Jakob, T., Christensen, L. H., Jabs, F. & Spillner, E. (2025). A Fully Human Monoclonal Antibody Isolated From a Beekeeper Targets the Immunodominant IgE Epitope of Api m 10. Journal of Investigational Allergology and Clinical Immunology, 35(1), 55-57. https://doi.org/10.18176/jiaci.1029
Hobolth, A., Boitard, S., Futschik, A. & Leblois, R. (2025). A matrix-analytical sampling formula for time-homogeneous coalescent processes under the infinite sites mutation model. Theoretical Population Biology, 163, 62-79. https://doi.org/10.1016/j.tpb.2025.03.002
Tang, Z., Doktor, F. G., Jaganathan, R., Palotás, J., Oomens, J., Hornekær, L. & Hammer, B. (2025). Anharmonic infrared spectra of cationic pyrene and superhydrogenated derivatives. Journal of Chemical Physics, 163(4), Article 044304. https://doi.org/10.1063/5.0276133
Anthi, A. K., Kolderup, A., Vaage, E. B., Bern, M., Benjakul, S., Tjärnhage, E., Ruso-Julve, F., Jensen, K. R., Lode, H. E., Vaysburd, M., Nilsen, J., Herigstad, M. L., Sakya, S. A., Tietze, L., Pilati, D., Nyquist-Andersen, M., Dürkoop, M., Gjølberg, T. T., Peng, L. ... Andersen, J. T. (2025). An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models. Nature Communications, 16(1), Article 3999. Advance online publication. https://doi.org/10.1038/s41467-025-59353-6
Nielsen, K. H. (2025). Anonyme tip om snyd. Weekendavisen, Sektion 4 (Ideer), 5.

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Revised 03.03.2026
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Kalinka Hansen