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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Hofmann, S. C., Pfender, N., Weckesser, S., Jakob, T., Blank, S., Spillner, E. & Huss-Marp, J. (2011). Reply. Journal of Allergy and Clinical Immunology, 128(1), 248. https://doi.org/10.1016/j.jaci.2011.02.020
Dupont, D. M., Madsen, J. B., Bøtkjær, K. A., Tavitian, B., Duconge, F., Kjems, J. & Andreasen, P. (2011). RNA aptamers to the cancer-associated proteins UPA and PAI-1 with therapeutic potential. Nucleic Acid Therapeutics, 21(5).
Lützelberger, M. & Kjems, J. (2011). S1 nuclease analysis of alternatively spliced mRNA. Methods in Molecular Biology, 703, 161-71. https://doi.org/10.1007/978-1-59745-248-9_11
Basaiawmoit, R. V., Oliveira, C. L. P., Runager, K., Sørensen, C. S., Behrens, M. A., Jonsson, B.-H., Kristensen, T., Klintworth, G. K., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2011). SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation. Journal of Molecular Biology, 408(3), 503-513. https://doi.org/10.1016/j.jmb.2011.02.052
Weber, M., Schneider, D., Prodöhl, A., Dreher, C., Becker, C., Underhaug, J., Svane, A. S. P., Malmendal, A., Nielsen, N. C. & Otzen, D. (2011). SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH. Journal of Molecular Biology, 407(4), 594-606. https://doi.org/10.1016/j.jmb.2011.02.005
Jepsen, M. B., Beerens, N., Nechyponuk-Zloy, V., Besenbacher, F., Kjems, J. & Birkedal, V. (2011). Single molecule FRET microscopy studies of tRNA annealing onto the HIV-1 genome. Poster session presented at International Bunsen Discussion Meeting Förster resonance energy transfer in life science, Germany.
Birkedal, V., Dong, M., Golas, M. M., Sander, B., Andersen, E. S., Gothelf, K. V., Besenbacher, F. & Kjems, J. (2011). Single molecule microscopy methods for the study of DNA origami structures. Microscopy Research and Technique, 74(7), 688-698. https://doi.org/10.1002/jemt.20962
Jahn, K., Olsen, E. M., Nielsen, M. M., Tørring, T., Mohammadzadegan, R., Andersen, E. S., Gothelf, K. V. & Kjems, J. (2011). Site-Specific Chemical Labeling of Long RNA Molecules. Bioconjugate Chemistry, 22(1), 95-100. https://doi.org/10.1021/bc100422k
Søbjerg, L. S., Lindhardt, A. T., Skrydstrup, T., Finster, K. & Meyer, R. L. (2011). Size control and catalytic activity of bio-supported palladium nanoparticles. Colloids and Surfaces B: Biointerfaces, 85(2), 373-378. https://doi.org/10.1016/j.colsurfb.2011.03.014
Wang, J., Jensen, U. B., Jensen, G. V., Shipovskov, S., Balakrishnan, V. S., Otzen, D., Pedersen, J. S., Besenbacher, F. & Sutherland, D. S. (2011). Soft Interactions at Nanoparticles Alter Protein Function and Conformation in a Size Dependent Manner. Nano Letters, 11(11), 4985-4991. https://doi.org/10.1021/nl202940k

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Revised 03.03.2026
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Kalinka Hansen