AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells

- Research news

An article from the Zelikin lab just published in Bioconjugate Chemistry has been selected as the American Chemical Society Editor´s Choice (the one article chosen each day from the entire ACS portfolio to be highlighted for quality and/or broad interest).

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

- Research news

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either…

Cell Membrane Vesicle Camouflaged Artificial Cells

- Research news

The integration of artificial and mammalian cells into semi-synthetic aggregates remains a challenge in bottom-up synthetic biology. Here, the fabrication of cell membrane vesicles (CMV) from HepG2 cells and their use as a coating for alginate microgels to produce camouflaged artificial cells (ACs) is demonstrated. These ACs are used for the assembly of either synthetic aggregates or semi-synthetic aggregates. In the first case, a predator-defendant and a liver-like synthetic aggregates are…

Researchers propose a roadmap towards the synthesis of life

- Research news

A new perspective article by 57 international researchers, including Associate Professor Ebbe Sloth Andersen, outlines a roadmap for the synthesis of life. The paper explores key traits like resilience, sustainability, and evolution, and how synthetic life could revolutionize biotechnology, medicine, and materials science.

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced FluorescenceClick to copy article link

- Research news

Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time. We study mono-, bi-,…

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Recent publications by network

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Ryberg, C., Pendlmayr, S., Pedersen, J. S., Nygaard, J. V., Lagerwall, J. P. F. & Städler, B. (2026). 3D-Printed Actuator Powered by Liquid Crystal Elastomer Muscles at the Water–Air Interface. Advanced Materials Technologies, Article e71401. Advance online publication. https://doi.org/10.1002/admt.71401
Li, B., Dong, M. & Li, Q. (2026). Achieving macroscale superlubricity and ultra-wear resistance via MXene-bridged graphene oxide coatings. Applied Surface Science, 745, Article 167480. https://doi.org/10.1016/j.apsusc.2026.167480
Bæk, Z. E. D., Macià, M. C., Skov, L. & Hobolth, A. (2026). Advanced Posterior Analyses of Hidden Markov Models: Finite Markov Chain Imbedding and Hybrid Decoding. Scandinavian journal of statistics. Advance online publication. https://doi.org/10.1111/sjos.70088
Amin, H., Šantl-Temkiv, T., Finster, K., Schlünssen, V., Sigsgaard, T., Wouters, I. M., Sørensen, M. T., Malinovschi, A., Thorarinsdottir, H. & Bertelsen, R. J. (2026). Airborne Movement of Antibiotic Resistance Genes Between Livestock Stables and Farmers’ Homes. Microorganisms, 14(4), Article 855. https://doi.org/10.3390/microorganisms14040855
Cai, Y., Lou, C., Tahir, M., Siqueira, A. C., Vogel, S., Wengel, J. & Howard, K. A. (2026). Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. In T. Yokota, R. Maruyama & H. Moriyama (Eds.), Gapmers: Methods and Protocols (pp. 213-226). Humana Press. https://doi.org/10.1007/978-1-0716-5476-7_14
Vestrheim, O., Zhao, H., Nielsen, A. B., Wili, N., Nielsen, N. C., Lyons, J. A., Mookerjee, R. P. & Städler, B. (2026). A Lipid-Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells. Angewandte Chemie - International Edition, 65(33), Article e5582949. https://doi.org/10.1002/anie.5582949
Xi, X., Zhang, Y., Zhao, D., Chen, F. & Howard, K. A. (2026). A modular “Catch-and-Play” platform for rapid T-cell engager target assembly for personalised cancer treatment. Signal Transduction and Targeted Therapy, 11(1), Article 18. https://doi.org/10.1038/s41392-025-02557-5
Hopkinson, A. T., Wilson, A. M., Pitfield, J., Muiña, A. T., Rácz, R., Mifsud, D. V., Herczku, P., Lakatos, G., Sulik, B., Juhász, Z., Biri, S., McCullough, R. W., Mason, N. J., Scavenius, C., Hornekær, L. & Ioppolo, S. (2026). An interstellar energetic and non-aqueous pathway to peptide formation. Nature Astronomy, 10(4), 531-539. https://doi.org/10.1038/s41550-025-02765-7
Schmidt, J. S., Rasmussen, N. S., Jensen, L. Z., Mostovaya, A., Holding, J. M., Sejr, M. K., Finster, K. & Šantl-Temkiv, T. (2026). A Novel Mechanism of Sea-Surface Microlayer Formation Driven by Terrestrial Runoff: A Source of Ice Nucleating Particles in Arctic Coastal Environments. Environmental Science and Technology, 60(9), 7026-7040. https://doi.org/10.1021/acs.est.5c13481
Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Youssef, S., Kjems, J. & Gothelf, K. V. (2026). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. Advanced Science, 13(10), Article e12844. https://doi.org/10.1002/advs.202512844

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Revised 03.03.2026
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André Walter