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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, K. H. (2017, Nov 5). Fra skrummel til bærbar: Her er historien om den personlige computer. https://videnskab.dk/teknologi-innovation/fra-skrummel-til-baerbar-her-er-historien-om-den-personlige-computer

Hirsch, C. (2017). From heavy-tailed Boolean models to scale-free Gilbert graphs. Brazilian Journal of Probability and Statistics, 31(1), 111-143.

Vestergård, G. L. & Nielsen, K. H. (2017). From the preserves of the educated elite to virtually everywhere: A content analysis of Danish science news in 1999 and 2012. Public Understanding of Science, 26(2), 220-234. https://doi.org/10.1177/0963662515603272, https://doi.org/10.1177/0963662515603272

Nielsen, K. H. (2017, Oct 15). Gav Danmark en hovedrolle i Fords bil-eventyr: Her er historien om samlebåndet. http://videnskab.dk/teknologi-innovation/gav-danmark-en-hovedrolle-i-fords-bil-eventyr-her-er-historien-om-samlebaandet

Nielsen, K. H. (2017). Ghetto. Weekendavisen, Sektion 4 (Ideer), 10.

Madsen, J. K., Kaspersen, J. D., Andersen, C. B., Nedergaard Pedersen, J., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2017). Glycolipid Biosurfactants Activate, Dimerize, and Stabilize Thermomyces lanuginosus Lipase in a pH-Dependent Fashion. Biochemistry, 56(32), 4256-4268. https://doi.org/10.1021/acs.biochem.7b00420

Hall, J. P., Gurung, S. P., Henle, J., Poidl, P., Andersson, J., Lincoln, P., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. & Cardin, C. J. (2017). Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects. Chemistry: A European Journal, 23(21), 4981-4985. https://doi.org/10.1002/chem.201605508

Santl-Temkiv, T., Amato, P., Gosewinkel, U. B., Thyrhaug, R., Charton, A., Chicot, B., Finster, K., Bratbak, G. & Löndahl, J. (2017). High-Flow-Rate Impinger for the Study of Concentration, Viability, Metabolic Activity, and Ice-Nucleation Activity of Airborne Bacteria. Environmental Science and Technology Library, 51(19), 11224–11234. https://doi.org/10.1021/acs.est.7b01480

Gong, X., Skrivergaard, S., Korsgaard, B., Schreiber, L., Marshall, I., Finster, K. & Schramm, A. (2017). High quality draft genome sequence of Janthinobacterium psychrotolerans sp. nov., isolated from a frozen freshwater pond. Standards in Genomic Sciences, 12(8), Article 8. https://doi.org/10.1186/s40793-017-0230-x

Nielsen, K. H. & Nielsen, H. (2017, Dec 18). How the US built a mysterious military camp under the Greenland ice sheet. http://sciencenordic.com/how-us-built-mysterious-military-camp-under-greenland-ice-sheet

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Kalinka Hansen