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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Bak, E. N., Zafirov, K., Merrison, J. P., Jensen, S. J. K., Nornberg, P., Gunnlaugsson, H. P. & Finster, K. (2017). Production of reactive oxygen species from abraded silicates. Implications for the reactivity of the Martian soil. Earth and Planetary Science Letters, 473, 113-121. https://doi.org/10.1016/j.epsl.2017.06.008

Santl-Temkiv, T., Rauter, U., Pilgaard, S., Tesson, I. S., Lange, R., Gunde-Cimerman, N., Svendsen, S., Massling, A. & Finster, K. (2017). Quantifying bioaerosols and proteinaceous ice nuclei that may impact atmospheric processes in the high Arctic. Poster session presented at Atmospheric Ice Nucleation conference, Leeds, United Kingdom.

V. Nair, R., Thankam Thomas, R., Sankar, V., Muhammad, H., Dong, MD. & Pillai, S. (2017). Rapid, Acid-Free Synthesis of High-Quality Graphene Quantum Dots for Aggregation Induced Sensing of Metal Ions and Bioimaging. ACS Omega, 2(11), 8051-8061. https://doi.org/10.1021/acsomega.7b01262

Westberg, M. (2017). Rational Design of Efficient Singlet Oxygen Photosensitizing Proteins.

Riber, C. F. & Zelikin, A. N. (2017). Recent advances in macromolecular prodrugs. Current Opinion in Colloid & Interface Science, 31, 1-9. https://doi.org/10.1016/j.cocis.2017.06.002

Kaspersen, J. D., Søndergaard, A., Madsen, D. J., Otzen, D. E. & Pedersen, J. S. (2017). Refolding of SDS-Unfolded Proteins by Nonionic Surfactants. Biophysical Journal, 112(8), 1609-1620. https://doi.org/10.1016/j.bpj.2017.03.013

Yang, Q., Hu, B., Jin, Y., Luo, Z., Besenbacher, F., Fang, L., Dong, L. & Dong, M. (2017). Regulating Surficial Catalysis Mechanism of Copper Metal by Manipulating Reactive Intermediate for Growth of Homogenous Bernal-Stacked Bilayer Graphene. Advanced Materials Interfaces, 4(17), Article 1700415. https://doi.org/10.1002/admi.201700415

Eriksen, C. B. (2017). Review of: Baker and Gibbs (eds.): Life Forms in the Thinking of the Long Eighteenth Century. Isis, 108(4), 907-909.

Weizmann, Y. & Andersen, E. S. (2017). RNA nanotechnology-The knots and folds of RNA nanoparticle engineering. MRS Bulletin, 42(12), 930-935. https://doi.org/10.1557/mrs.2017.277

Mooney, C. M., Jimenez-Mateos, E. M., Engel, T., Mooney, C., Diviney, M., Venø, M. T., Kjems, J., Farrell, M. A., O'Brien, D. F., Delanty, N. & Henshall, D. C. (2017). RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis. Scientific Reports, 7, Article 41517. https://doi.org/10.1038/srep41517

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Kalinka Hansen