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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Fejerskov, B. & Zelikin, A. N. (2012). Substrate mediated enzyme prodrug therapy. PLoS One, 7(11), e49619. https://doi.org/10.1371/journal.pone.0049619

Finster, K. (2012). Sulfur disporportionators as a model of a chemolithoautotrophic "LUCA". Abstract from 12th European Workshop on Astrobiology, Stockholm, Sweden.

Rigau, L. H., Jensen, B. E. B., Fjeldsø, K., Postma, A., Li, Goldie, Albericio, Zelikin, A. N. & Stadler, B. M. (2012). Surface-Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome-Aided Delivery of Therapeutic Small Molecules. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201200092

Jensen, B. E. B., Alves, M.-H., Fejerskov, B., Stadler, B. & Zelikin, A. N. (2012). Surface adhered poly(vinyl alcohol) physical hydrogels as tools for rational design of intelligent biointerfaces. Soft Matter, 8, 4625-4634. https://doi.org/10.1039/C2SM07075H

Zhao, H., Chen, D., Liu, B., Zhang, S. & Dong, M. (2012). Synthesis and properties of one-dimensional ZnO nanostructures and their integration into dye-sensitive solar cells. Nanoscience & Nanotechnology - Asia, 2(1), 11-27. https://doi.org/10.2174/2210681211202010011

Funder, E. D., Jensen, A. B., Tørring, T., Kodal, A. L. B., Azcargorta, A. R. & Gothelf, K. V. (2012). Synthesis of Dopamine and Serotonin Derivatives for Immobilization on a Solid Support. Journal of Organic Chemistry, 77(7), 3134-3142. https://doi.org/10.1021/jo2025477

Temkiv, T. S., Finster, K. & Gosewinkel, U. B. (2012). The application of a decontamination technique within the study of low bacterial density environments. Abstract from 12th European Workshop on Astrobiology, Stockholm, Sweden. https://doi.org/10.1111/j.1574-6941.2012.01402.x

Temkiv, T. S., Finster, K. & Gosewinkel, U. B. (2012). The application of a decontamination technique within the study of low bacterial density environments. Poster session presented at 12th European Workshop on Astrobiology, Stockholm, Sweden. https://doi.org/10.1111/j.1574-6941.2012.01402.x

Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J. R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J. R., Mullikin, J. C., Meader, S. J., Ponting, C. P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoç, E. ... Pääbo, S. (2012). The bonobo genome compared with the chimpanzee and human genomes. Nature, 486(7404), 527-31. https://doi.org/10.1038/nature11128

Mennella, V., Hornekær, L., Thrower, J. & Accolla, M. (2012). The Catalytic Role of Coronene for Molecular Hydrogen Formation. Astrophysical Journal, 745(1), L2. https://doi.org/10.1088/2041-8205/745/1/L2

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