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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Ulstrup, S., Andersen, M., Bianchi, M., Barreto, L., Hammer, B., Hornekær, L. & Hofmann, P. (2014). Sequential Oxygen and Alkali Intercalation of Epitaxial Graphene on Ir(111): Enhanced Many-Body Effects and Formation of pn-interfaces. 2D materials, 1, Article 025002.

Kronqvist, N., Otikovs, M., Chmyrov, V., Chen, G., Andersson, M., Nordling, K., Landreh, M., Sarr, M., Jörnvall, H., Wennmalm, S., Widengren, J., Meng, Q., Rising, A., Otzen, D., Knight, S. D., Jaudzems, K. & Johansson, J. (2014). Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation. Nature Communications, 5, Article 3254. https://doi.org/10.1038/ncomms4254

Tørring, T., Helmig, S. W., Ogilby, P. R. & Gothelf, K. V. (2014). Singlet Oxygen in DNA Nanotechnology. Accounts of Chemical Research, 47(6), 1799-1806. https://doi.org/10.1021/ar500034y

Miclaus, T., Bochenkov, V., Ogaki, R., Howard, K. & Sutherland, D. S. (2014). Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes. Nano Letters, 14(4), 2086-2093. https://doi.org/10.1021/nl500277c

Nawroth, I., Mueller, F., Basyuk, E., Beerens, N., Rahbek, U. L., Darzacq, X., Bertrand, E., Kjems, J. & Schmidt, U. (2014). Stable assembly of HIV-1 export complexes occurs cotranscriptionally. RNA, 20(1), 1-8. https://doi.org/10.1261/rna.038182.113

Basse-O'Connor, A., Graversen, S.-E. & Pedersen, J. (2014). Stochastic integration on the real line. Theory of Probability and Its Applications, 58(2), 193-213. https://doi.org/10.1137/S0040585X97986540

Nam, K., Munch, K., Hobolth, A., Y. Dutheil, J., Veeramah, K., Woerner, A., F. Hammer, M., Ape Genome Diversity Project, G., Mailund, T. & H. Schierup, M. (2014). Strong selective sweeps associated with ampliconic regions in great ape X chromosomes. ArXiv.

Lyons, J. A., Parker, J. L., Solcan, N., Brinth, A., Li, D., Shah, S. T., Caffrey, M. & Newstead, S. (2014). Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Reports, 15(8), 886-893. https://doi.org/10.15252/embr.201338403

Ling, M., Santl-Temkiv, T., Finster, K. & Boesen, T. (2014). Structural studies of bacterial ice nucleation proteins and their relevance for atmospheric processes. Poster session presented at 2nd Ice Binding Conference, Sapporo, Japan.

Zhang, S., Jiang, Z., Besenbacher, F. & Dong, M. (2014). Study Sub-Membrane Structure and Corresponding Functions of Conductive Bacteria Cable by SPMs. Biophysical Journal, 106(2), 799A-799A.

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