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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Andersen, M., Hornekær, L. & Hammer, B. (2012). Graphene on metal surfaces and its hydrogen adsorption: A meta-GGA functional study. Physical Review B, 86(8), 085405. https://doi.org/10.1103/PhysRevB.86.085405

Temkiv, T. S., Finster, K., Dittmar, T., Hansen, B. M., Thyrhaug, R., Nielsen, N. W. & Karlson, U. G. (2012). Hailstones: a window into microbial life in storm clouds. Abstract from ISME Conference 2012, København, Denmark.

Temkiv, T. S., Finster, K., Dittmar, T., Hansen, B. M., Thyrhaug, R., Nielsen, N. W. & Gosewinkel, U. B. (2012). Hailstones: a window into microbial life in storm clouds. Poster session presented at ISME Conference 2012, København, Denmark.

Tarpgaard, I. H., Røy, H., Kjeldsen, K. U., Finster, K. & Jørgensen, B. B. (2012). High affinity sulfate reduction kinetics in marine sediment. Abstract from ISME Conference 2012, København, Denmark.

Ulstrup, S., Bianchi, M., Guan, D., Baraldi, A., Alfè, D., Hornekær, L. & Hofmann, P. (2012). High-temperature behavior of supported graphene: Electron-phonon coupling and substrate-induced doping. Physical Review B, 86. https://doi.org/10.1103/PhysRevB.86.161402

Cockell, C. S., Voytek, M. A., Gronstal, A. L., Finster, K., Kirshtein, J. D., Howard, K., Reitner, J., Gohn, G. S., Sanford, W. E., Horton, Jr., J. W., Kallmeyer, J., Kelly, L. & Powars, D. S. (2012). Impact disruption and recovery of the deep subsurface biosphere. Astrobiology, 12(3). https://doi.org/10.1089/ast.2011.0722

Scally, A., Dutheil, J. Y., Hillier, L. W., Jordan, G. E., Goodhead, I., Herrero, J., Hobolth, A., Lappalainen, T., Mailund, T., Marques-Bonet, T., McCarthy, S., Montgomery, S. H., Schwalie, P. C., Tang, Y. A., Ward, M. C., Xue, Y., Yngvadottir, B., Alkan, C., Andersen, L. N. ... Durbin, R. (2012). Insights into hominid evolution from the gorilla genome sequence. Nature, 483(7388), 169-75. https://doi.org/10.1038/nature10842

Zelikin, A. N. & Stadler, B. M. (2012). Intelligent Polymer Thin Films and Coatings for Drug Delivery. In H. M. Grandin & M. Textor (Eds.), Intelligent Surfaces in Biotechnology - Scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications John Wiley & Sons Ltd.

Schyth, B. D., Bramsen, J. B., Pakula, M. M., Larashati, S., Kjems, J., Wengel, J. & Lorenzen, N. (2012). In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important. Nucleic Acids Research, 40(10), 4653-4665. https://doi.org/10.1093/nar/gks033

Nielsen, K. H. (2012). Kan man blande olie og demokrati? Videnskab.dk. http://videnskab.dk/blog/kan-man-blande-olie-og-demokrati

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