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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Vu-Quang, H., Vinding, M. S., Jakobsen, M., Song, P., Dagnaes-Hansen, F., Nielsen, N. C. & Kjems, J. (2019). Imaging rheumatoid arthritis in mice using combined near infrared and ¹⁹F magnetic resonance modalities. Scientific Reports, 9, Article 14314. https://doi.org/10.1038/s41598-019-50043-0

Rasmussen, C. B., Christiansen, G., Vad, B. S., Lynggaard, C., Enghild, J. J., Andreasen, M. & Otzen, D. (2019). Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation. Protein Science, 28(3), 633-642. https://doi.org/10.1002/pro.3566

Fredsøe, J., Rasmussen, A. K. I., Laursen, E. B., Cai, Y., Howard, K. A., Pedersen, B. G., Borre, M., Mouritzen, P., Òrntoft, T. & Sørensen, K. D. (2019). Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model (uCaP) for Prostate Cancer in Cell-Free Urine. Clinical Chemistry, 65(4), 540-548. https://doi.org/10.1373/clinchem.2018.296681

Rasmussen, P., Spillner, E. & Hoffmann, H. J. (2019). Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells. Immunology Letters, 210, 40-46. https://doi.org/10.1016/j.imlet.2019.04.003

Amagat, J. & Chen, M. (2019). Injectable PLCL/gelatin core-shell nanofibers support noninvasive 3D delivery of stem cells. International Journal of Pharmaceutics, 568(September), Article 118566. https://doi.org/10.1016/j.ijpharm.2019.118566

Meer, M. T., Dillion, R., Nielsen, S. M., Walther, R., Meyer, R. L., Daamen, W. F., Van Den Heuvel, L. P., Van Der Vliet, J. A., Lomme, R. M. L. M., Hoogeveen, Y. L., Schultze Kool, L. J., Schaffer, J. E. & Zelikin, A. N. (2019). Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs. Chemical Communications, 55(4), 443-446. https://doi.org/10.1039/c8cc08737g

Brodszkij, E., Hviid, M. J., Ade, C., Schattling, P. S., Burmeister, M., Szilagyi, S., Gal, N., Zhu, C., Han, X. & Städler, B. (2019). Interaction of pH-responsive polyanions with phospholipid membranes. Polymer Chemistry, 10(44), 5992-5997. https://doi.org/10.1039/c9py00924h

Hong, Y., Wang, S., Li, Q., Song, X., Wang, Z., Zhang, X., Besenbacher, F. & Dong, M. (2019). Interfacial icelike water local doping of graphene. Nanoscale, 11(41), 19334-19340. https://doi.org/10.1039/c9nr05832j

Knudsen, L. J., Nielsen, S. D.-H., Rauh, V., Otzen, D., Dekker, P. J. T. & Larsen, L. B. (2019). Interrelations between chemical changes in lactose-free UHT milk. Abstract from 16th Symposium on Milk Genomics and Human Health, Aarhus, Denmark.

Knudsen, L. J., Nielsen, S. D., Rauh, V., Otzen, D., Dekker, P. J. T. & Larsen, L. B. (2019). Interrelations between chemical changes in lactose-free UHT milk. Abstract from Sandbjerg Seminar 2019, Sønderborg, Denmark.

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Kalinka Hansen