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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Pan, Y.-X., Liu, C.-J., Yu, Y., Zhang, S. & Dong, M. (2012). 2D-oriented self-assembly of peptides induced by hydrated electrons. Chemistry: A European Journal, 18(46), 14614-14617. https://doi.org/10.1002/chem.201200745

Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C. & Kjems, J. (2012). Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors. Nanoscale, 4(7), 2352-2361 . https://doi.org/10.1039/C2NR11554A

Daniel, C., Venø, M. T., Ekdahl, Y., Kjems, J. & Öhman, M. (2012). A distant cis acting intronic element induces site-selective RNA editing. Nucleic Acids Research, 40(19), 9876-9886. https://doi.org/10.1093/nar/gks691

Eriksen, C. B. (2012). Af en ung filologs papirer: Anmeldelse af Friedrich Nietzsche: Friedrich Nietzsche og antikken. Semikolon (Aarhus C), 13(24), 70-71.

Andersen, K. K., Wang, H. & Otzen, D. (2012). A Kinetic Analysis of the Folding and Unfolding of OmpA in Urea and Guaninidinium Chloride: Single and Parallel Pathways. Biochemistry, 51(42), 8371-8383. https://doi.org/10.1021/bi300974y

Hobolth, A. (2012). Ancestral population genomics. In M. Anisimova (Ed.), Evolutionary Genomics: Statistical and Computational Methods (Vol. 856, pp. 293-313). Springer.

Mailund, T., Halager, A. E., Westergaard, M., Dutheil, J. Y., Munch, K., Andersen, L. N., Lunter, G., Prüfer, K., Scally, A., Hobolth, A. & Schierup, M. H. (2012). A New Isolation with Migration Model along Complete Genomes Infers Very Different Divergence Processes among Closely Related Great Ape Species. PLoS Genetics, 8(12), e1003125. https://doi.org/10.1371/journal.pgen.1003125

Chen, M., Liu, Q., Liu, P., Wang, C., Li, Y.-M., Dong, M., Besenbacher, F., Busuttil, K. & Zhang, S. (2012). An investigation into the formation of annular aggregates of human islet amyloid polypeptide on tantalum oxide surfaces. Chemistry: A European Journal, 18(9), 2493-7. https://doi.org/10.1002/chem.201102215

Wehr, C., Müller, F., Schüler, J., Tomann, T., Nitschke, C., Seismann, H., Spillner, E., Klingner, K., Schneider-Merck, T., Binder, M., Fiebig, H.-H., Mertelsmann, R. & Trepel, M. (2012). Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model. International Journal of Cancer, 131(2), E10-20. https://doi.org/10.1002/ijc.26464

Weber, M., Tome, L., Otzen, D. & Schneider, D. (2012). A Ser residue influences the structure and stability of a Pro-kinked transmembrane helix dimer. BBA General Subjects, 1818(9), 2103-7. https://doi.org/10.1016/j.bbamem.2012.04.003

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