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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Pimenta, F. M., Jensen, R. L., Holmegaard, L., Esipova, T. V., Westberg, M., Breitenbach, T. & Ogilby, P. R. (2012). Singlet-Oxygen-Mediated Cell Death Using Spatially-Localized Two-Photon Excitation of an Extracellular Sensitizer. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 116(34), 10234-10246. https://doi.org/10.1021/jp304954m

Nielsen, K. H. (2012). Sociological Ambivalence in the Commodification of Academic Research. Science as Culture, 21(3), 405-408. https://doi.org/10.1080/09505431.2011.640317

Basse-O'Connor, A., Graversen, S.-E. & Pedersen, J. (2012). Some classes of proper integrals and generalized Ornstein-Uhlenbeck processes. In C. Donati-Martin, A. Lejay & A. Rouault (Eds.), Séminaire de Probabilités XLIV (Vol. 2046, pp. 61-74). Springer. https://doi.org/10.1007/978-3-642-27461-9_3

Venø, M. T., Bramsen, J. B., Bendixen, C., Panitz, F., Holm, I. E., Öhman, M. & Kjems, J. (2012). Spatio-temporal regulation of ADAR editing during development in porcine neural tissues. RNA Biology, 9(8), 1054-1065. https://doi.org/10.4161/rna.21082

Damgaard, C. K., Lykke-Andersen, S. & Kjems, J. (2012). Stable Cell Lines with Splicing Reporters. In S. Stamm, C. W. J. Smith & R. Luhrmann (Eds.), Alternative pre-mRNA Splicing: Theory and Protocols (1 ed., pp. 408-414). Wiley-VCH. https://doi.org/10.1002/9783527636778.ch38

Nielsen, K. H. (2012). Strategic science communication in context. Abstract from Quality, Honesty and Beauty in Science and Technology Communication, Florence, Italy. http://www.pcst2012.org/images/BookofAbstracts.pdf

Nielsen, K. H. (2012). Strategic science communication in practice. Abstract from Quality, Honesty and Beauty in Science and Technology Communication, Florence, Italy. http://www.pcst2012.org/images/BookofAbstracts.pdf

Temkiv, T. S., Finster, K. & Gosewinkel, U. B. (2012). Studying low bacterial density environments: Reducing background contamination problems with sensitive DNA-targeting techniques. Poster session presented at ISME Conference 2012, København, Denmark.

Temkiv, T. S., Finster, K. & Gosewinkel, U. B. (2012). Studying low bacterial density environments: Reducing background contamination problems with sensitive DNA-targeting techniques. Abstract from ISME Conference 2012, København, Denmark.

Nielsen, K. H., Harbsmeier, M. & Ries, C. (2012). Studying Scientists and Scholars in the Field. In K. H. Nielsen, M. Harbsmeier & C. J. Ries (Eds.), Scientists and Scholars in the Field: Studies in the History of Fieldwork and Expeditions (pp. 9-28). Aarhus Universitetsforlag.

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