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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Brun, M., Hirsch, C. P., Juhász, P. & Otto, M. (2025). Random Connection Hypergraphs. https://arxiv.org/pdf/2407.16334

Pedersen, A. B., Andersen, D. G., Jakobsen, J. H., Montasell, M. C. & Zelikin, A. N. (2025). Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells. Bioconjugate Chemistry, 36(4), 782-791. https://doi.org/10.1021/acs.bioconjchem.5c00043

Skovborg, G., Svejsø, F. H., Müller, C., Jensen, B. N., Jensen, J. G., Majidi, S. E., Matthiesen, C. L. & Chen, M. (2025). Replication of patient specific circulating tumor cells on a microfibrous filter for drug screening. Nanoscale, 17(18), 11592-11604. https://doi.org/10.1039/d4nr05294c

Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096

Jiang, Y. & Kjems, J. (2025). RNA denaturation underlies circular RNA separation. Nucleic Acids Research, 53(21), Article gkaf1160. https://doi.org/10.1093/nar/gkaf1160

Nowak, J. S., Olesen, S., Tian, P., Bærentsen, R. L., Brodersen, D. E. & Otzen, D. E. (2025). Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase. Biochimica et Biophysica Acta - Proteins and Proteomics, 1873(4), Article 141072. https://doi.org/10.1016/j.bbapap.2025.141072

Kristoffersen, E. L., McRae, E. K. S., Sørensen, N. R., Holliger, P. & Andersen, E. S. (2025). Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis. Nucleic Acids Research, 53(11), Article gkaf057. https://doi.org/10.1093/nar/gkaf057

Fage-Butler, A., Ledderer, L. & Nielsen, K. H. (Eds.) (2025). Science communication and trust. Palgrave Macmillan. https://doi.org/10.1007/978-981-96-1289-5

Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217

Xia, D., Shi, T., Cao, W., Li, B., Wang, D., Liang, C. & Dong, M. (2025). Self-healing hydrogel based on polyvinyl alcohol/dextran with hyperglycemia-triggered cascade enzyme catalytic activity promotes diabetic wound healing. Journal of Colloid and Interface Science, 693, Article 137615. https://doi.org/10.1016/j.jcis.2025.137615

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Kalinka Hansen