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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. (2010). Nyt fra vestfronten: Er klimakrigen ved at være forbi? Videnskab.dk. http://videnskab.dk/content/dk/blogs/bag_om_videnskaben/nyt_fra_vestfronten_er_klimakrigen_ved_at_vare_forbi

Otzen, D. (2010). Occupancy of non-annular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein. Biochemistry.

Triano, I., Barrera, F. N., Renart, M. L., Molina, M. L., Fernández-Ballester, G., Poveda, J. A., Fernández, A. M., Encinar, J. A., Ferrer-Montiel, A. V., Otzen, D. & González-Ros, J. M. (2010). Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein. Biochemistry, 49(25), 5397-5404. https://doi.org/10.1021/bi1003712

Nielsen, K. H. (2010). Ole Rømers observatorium: Stjernekiggeriet. In 1001 fortællinger om Danmark Kulturarvsstyrelsen. http://www.kulturarv.dk/1001fortaellinger/da_DK/ole-roemers-observatorium/main

Vad, B. S., Bertelsen, K., Johansen, C. H., Pedersen, J. M., Skrydstrup, T., Nielsen, N. C. & Otzen, D. E. (2010). Pardaxin permeabilizes vesicles more efficiently by pore formation than by disruption. Biophysical Journal, 98(4), 576-85. https://doi.org/10.1016/j.bpj.2009.08.063

Basse-O'Connor, A. & Graversen, S.-E. (2010). Path and semimartingale properties of chaos processes. Stochastic Processes and Their Applications, 120(4), 522-540. https://doi.org/10.1016/j.spa.2009.12.001

Zelikin, A. N., Price, A. & Stadler, B. (2010). Poly(Methacrylic Acid) Polymer Hydrogel Capsules: Drug Carriers, Sub-compartmentalized Microreactors, Artificial Organelles. Small, 6(20), 2201-2207.

Nielsen, K. H. (2010). Postcolonial partnerships: deep sea research, media coverage and (inter)national narratives on the Galathea Deep Sea Expedition from 1950 to 1952. British Journal for the History of Science, 43(1), 75-98. https://doi.org/10.1017/S0007087409990045

Andersen, E. S. (2010). Prediction and design of DNA and RNA structures. New Biotechnology, 27(3), 184-193.

Nielsen, K. H. (2010). Public Understanding of Research. In S. H. Priest (Ed.), Encyclopedia of Science and Technology Communication (pp. 613-616). SAGE Publications.

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