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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, S. B. & Otzen, D. E. (2010). Impact of the antimicrobial peptide Novicidin on membrane structure and integrity. Journal of Colloid and Interface Science, 345(2), 248-256. https://doi.org/10.1016/j.jcis.2010.01.065

Otzen, D. (2010). Institutional nonconformism: the many levels of glucagon polymorphism. FEBS journal.

Krüger, A. C., Raarup, M. K., Nielsen, M. M., Kristensen, M., Besenbacher, F., Kjems, J. & Birkedal, V. (2010). Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level. European Biophysics Journal, 39(9), 1343-1350. https://doi.org/10.1007/s00249-010-0587-x

Nawroth, I., Alsner, J., Behlke, M. A., Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J. (2010). Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis. Radiotherapy & Oncology, 97(1), 143-8. https://doi.org/10.1016/j.radonc.2010.09.010

Debnath, D., Nielsen, K. L. & Otzen, D. E. (2010). In vitro association of fragments of a beta-sheet membrane protein. Advances in Biophysical Chemistry, 148(1-3), 112-20. https://doi.org/10.1016/j.bpc.2010.03.004

Nielsen, K. H. (2010). Kirurgisk Akademi, Bredgade: Den anatomiske revolution. In 1001 fortællinger om Danmark Kulturarvsstyrelsen. http://www.kulturarv.dk/1001fortaellinger/da_DK/kirurgisk-akademi-bredgade/main

Nielsen, K. H. (2010). Klimapolitik bygger på forskning i støbeskeen. Videnskab.dk. http://videnskab.dk/content/dk/blogs/bag_om_videnskaben/klimapolitik_bygger_pa_forskning_i_stobeskeen

Nielsen, K. H. (2010). Latour, Bruno. In S. H. Priest (Ed.), Encyclopedia of Science and Technology Communication (pp. 444-446). SAGE Publications.

Bally, M., Bailey, K., Sugihara, K., Grieshaber, D., Voros, J. & Stadler, B. (2010). Liposome and Lipid Bilayer Arrays Towards Biosensing Applications. Small, 6(22), 2481-2497.

Kartashov, A. V., Serafini, G., Dong, M., Shipovskov, S., Gazaryan, I., Besenbacher, F. & Ferapontova, E. (2010). Long-range electron transfer in recombinant peroxidases anisotropically orientated on gold electrodes. Physical Chemistry Chemical Physics, 12, 10098-10107. https://doi.org/10.1039/c0cp00605j

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Kalinka Hansen