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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Pijanka, J. K., Kimball, E. C., Pease, M. E., Abass, A., Sorensen, T., Nguyen, T. D., Quigley, H. A. & Boote, C. (2014). Changes in scleral collagen organization in murine chronic experimental glaucoma. Investigative Ophthalmology & Visual Science, 55(10), 6554-64. https://doi.org/10.1167/iovs.14-15047

Rasmussen, A. J. & Ebbesen, M. (2014). Characteristics, Properties, and Ethical Considerations of Carbon Nanotubes in Biomedical Applications. NanoEthics, 8(1), 29-48. https://doi.org/10.1007/s11569-014-0187-9

Ma, Z., Yang, C., Song, W., Wang, Q., Kjems, J. & Gao, S. (2014). Chitosan Hydrogel as siRNA vector for prolonged gene silencing. Journal of Nanobiotechnology, 12(23), 1-9. https://doi.org/10.1186/1477-3155-12-23

Yang, C., Nilsson, L., Cheema, M. U., Wang, Y., Frøkiær, J., Gao, S., Kjems, J. & Nørregaard, R. (2014). Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice. Theranostics, 5(2), 110-123. https://doi.org/10.7150/thno.9717

Nielsen, K. H., Nielsen, H. & Martin-Nielsen, J. (2014). City under the Ice: The Closed World of Camp Century in Cold War Culture. Science as Culture, 23(4), 443-464. https://doi.org/10.1080/09505431.2014.884063

Paslawski, W., Mysling, S., Thomsen, K., Jørgensen, T. J. D. & Otzen, D. (2014). Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry. Angewandte Chemie International Edition, 53(29), 7560-7563. https://doi.org/10.1002/anie.201400491

Knudsen, M., Søndergaard, D. & Pedersen, C. N. S. (2014). Combinatorics of Non-Ribosomal Peptide Synthetases.

Jeppesen, D. K., Hvam, M. L., Primdahl-Bengtson, B., Boysen, A. T., Whitehead, B., Dyrskjøt, L., Orntoft, T. F., Howard, K. & Ostenfeld, M. S. (2014). Comparative analysis of discrete exosome fractions obtained by differential centrifugation. Journal of Extracellular Vesicles, 3, 1-16. Article 25011. https://doi.org/10.3402/jev.v3.25011

Poulsen, E. T., Runager, K., Risør, M. W., Dyrlund, T. F., Scavenius, C., Karring, H., Praetorius, J., Vorum, H., Otzen, D. E., Klintworth, G. K. & Enghild, J. J. (2014). Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene. Proteomics - Clinical Applications, 8(3-4), 168-177. https://doi.org/10.1002/prca.201300058

Köhler, J., Blank, S., Müller, S., Bantleon, F., Frick, M., Huss-Marp, J., Lidholm, J., Spillner, E. & Jakob, T. (2014). Component resolution reveals additional major allergens in patients with honeybee venom allergy. Journal of Allergy and Clinical Immunology, 133(5), 1383-1389.e6. https://doi.org/10.1016/j.jaci.2013.10.060

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Kalinka Hansen