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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Sljivancanin, Z., Andersen, M., Hornekær, L. & Hammer, B. (2011). Structure and stability of small H clusters on graphene. Physical Review B, 83(20).

Andersen, L. N. (2011). Subexponential loss rate asymptotics for Lévy processes. Mathematical Methods of Operations Research, 73(1), 91-108. https://doi.org/10.1007/s00186-010-0335-0

Yde J.C., T.G. Barcena and K. Finster (2011). Subglacial and proglacial response to climate change. In Climate Change - Geophysical Foundations and Ecological Effects INTECH.

Spillner, E., Laursen, N. S., Andersen, K. R., Sottrup-Jensen, L., Andersen, G. R. & Braren, I. (2011). Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. EMBO Journal, 30(3), 606-616. https://doi.org/10.1038/emboj.2010.341

Hobolth, A. & Jensen, J. L. (2011). Summary statistics for endpoint-conditioned continuous-time Markov chains. Journal of Applied Probability, 48(4), 911-924. https://doi.org/10.1239/jap/1324046009

Debnath, D. K., Basaiawmoit, R. V., Nielsen, K. L. & Otzen, D. E. (2011). The role of membrane properties in Mistic folding and dimerisation. Protein Engineering Design and Selection (Print), 24(1-2), 89-97. https://doi.org/10.1093/protein/gzq095

Liu, L., Busuttil, K., Zhang, S., Yang, Y., Wang, C., Besenbacher, F. & Dong, M. (2011). The role of self-assembling polypeptides in building nanomaterials. Physical Chemistry Chemical Physics, 13, 17435-17444. https://doi.org/10.1039/c1cp21338e

Chen, M., Hein, S., Le, D. Q. S., Nygaard, J. V., Bünger, C. & Kjems, J. (2011). TISSUE SCAFFOLD WITH CONTROLLED DRUG RELEASE. (Patent No. PCT/DK2011/050381).

Chandrawati, R., Odermatt, P., Chong, S.-F., Price, A., Stadler, B. & Caruso, F. (2011). Triggered Cargo Release by Encapsulated Enzymatic Catalysis in Capsosomes. Nano Letters, 11(11), 4958–4963 ,.