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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Hua, Y., Larsen, N., Kalyana-Sundaram, S., Kjems, J., Chinnaiyan, A. M. & Peter, M. E. (2013). miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers. BMC Genomics, 14(179), 1-18. https://doi.org/10.1186/1471-2164-14-179

Bredehorst, R., Grunwald, T., Ollert, M., Schmidt-Weber, C. & Spillner, E. (2013). Modulation of effector T cell responses by local depletion of complement component C3.

Gonzalez, B. B., Nielsen, E. J. B., Thomsen, T. B. & Howard, K. (2013). Mucosal Delivery of RNAi Therapeutics. In K. A. Howard (Ed.), RNA Interference from Biology to Therapeutics (pp. 97-125). Springer. http://link.springer.com/chapter/10.1007%2F978-1-4614-4744-3_5#page-1

Nielsen, S. R., Besenbacher, F. & Chen, M. (2013). Mussel inspired surface functionalization of electrospun nanofibers for bio-applications. Physical Chemistry Chemical Physics, 15(40). https://doi.org/10.1039/c3cp52651h

Underhaug, J., Koldsø, H., Runager, K., Nielsen, J. T., Sørensen, C. S., Kristensen, T., Otzen, D., Karring, H., Malmendal, A., Schiøtt, B., Enghild, J. J. & Nielsen, N. C. (2013). Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization. BBA General Subjects, 1834(12), 2812–2822. https://doi.org/10.1016/j.bbapap.2013.10.008

Wohl, B. M., Smith, A. A. A., Kryger, M. B. L. & Zelikin, A. N. (2013). Narrow Therapeutic Window of Ribavirin as an Inhibitor of Nitric Oxide Synthesis is Broadened by Macromolecular Prodrugs. Biomacromolecules, 14(11), 3916-26. https://doi.org/10.1021/bm401048s

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K. & Kjems, J. (2013). Natural RNA circles function as efficient microRNA sponges. Nature, 495, 384-388. https://doi.org/10.1038/nature11993

Quinones, J. P., Gothelf, K. V., Kjems, J., Caballero, A. M. H., Schmidt, C. & Covas, C. P. (2013). N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin E. Carbohydrate Polymers, 91(1), 143-151. https://doi.org/10.1016/j.carbpol.2012.07.080

Quinones, J. P., Gothelf, K. V., Kjems, J., Heras, A., Schmidt, C. & Peniche, C. (2013). Novel Self-Assembled Nanoparticles of Testosterone-Modified Glycol Chitosan and Fructose Chitosan for Controlled Release. Journal of Biomaterials and Tissue Engineering, 3(1), 164-172. https://doi.org/10.1166/jbt.2013.1071

Balakrishnan, V. S., Vad, B. S. & Otzen, D. (2013). Novicidin's membrane permeabilizing activity is driven by membrane partitioning but not by helicity: A biophysical study of the impact of lipid charge and cholesterol. BBA General Subjects, 1834(6), 996-1002. https://doi.org/10.1016/j.bbapap.2013.03.025

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Kalinka Hansen