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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Kurnik, M., Sahin, C., Andersen, C. B., Lorenzen, N., Giehm, L., Mohammad-Beigi, H., Jessen, C. M., Pedersen, J. S., Christiansen, G., Petersen, S. V., Staal, R., Krishnamurthy, G., Pitts, K., Reinhart, P. H., Mulder, F. A. A., Mente, S., Hirst, W. D. & Otzen, D. E. (2018). Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State. Cell Chemical Biology, 25(11), 1389-1402.e9. https://doi.org/10.1016/j.chembiol.2018.08.005

Yang, T., Zelikin, A. N. & Chandrawati, R. (2018). Progress and Promise of Nitric Oxide-Releasing Platforms. Advanced Science, 5(6), Article 1701043. https://doi.org/10.1002/advs.201701043

Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V., Meyer, R. L. & Otzen, D. E. (2018). Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms. Journal of Molecular Biology, 430(20), 3751-3763. https://doi.org/10.1016/j.jmb.2018.06.043

Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, T., Christiansen, G. & Otzen, D. E. (2018). Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation. FEBS Letters, 592(9), 1484-1496. https://doi.org/10.1002/1873-3468.13038

Bortolini, C., Klausen, L. H., Hoffmann, S. V., Jones, N. C., Saadeh, D., Wang, Z., Knowles, T. P. J. & Dong, MD. (2018). Rapid Growth of Acetylated Aβ(16–20) into Macroscopic Crystals. ACS Nano, 12(6), 5408-5416. https://doi.org/10.1021/acsnano.8b00448

Nielsen, M. M., Tataru, P., Madsen, T., Hobolth, A. & Pedersen, J. S. (2018). Regmex: A statistical tool for exploring motifs in ranked sequence lists from genomics experiments. Algorithms for Molecular Biology, 13(1), Article 17. https://doi.org/10.1186/s13015-018-0135-2

Wang, Y., Su, Y., Wang, Z., Zhang, Z., Han, X., Dong, MD., Cui, L. & Chen, M. (2018). Reversible conductivity recovery of highly sensitive flexible devices by water vapor. npj Flexible Electronics, 2(1), Article 31. https://doi.org/10.1038/s41528-018-0043-z

Li, Q., Froning, J. P., Pykal, M., Zhang, S., Wang, Z., Vondrák, M., Banáš, P., Čépe, K., Jurečka, P., Šponer, J., Zbořil, R., Dong, M. & Otyepka, M. (2018). RNA nanopatterning on graphene. 2D materials, 5(3), Article 031006. https://doi.org/10.1088/2053-1583/aabdf7

Nedergaard Pedersen, J., Wilhelmus Johannes Maria Frederix, P., Skov Pedersen, J., Marrink, S. J. & Otzen, D. (2018). Role of charge and hydrophobicity in liprotide formation: a molecular dynamics study with experimental constraints. ChemBioChem, 19(3), 263–271. https://doi.org/10.1002/cbic.201700496

Nielsen, K. H. (2018). Rorschach-test. Weekendavisen, Sektion 4 (Ideer), 10.

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Kalinka Hansen