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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Ling, M. L., Wex, H., Grawe, S., Jakobsson, J., Londahl, J., Hartmann, S., Finster, K., Boesen, T. & Santl-Temkiv, T. (2018). Effects of Ice Nucleation Protein Repeat Number and Oligomerization Level on Ice Nucleation Activity. Journal of Geophysical Research: Atmospheres, 123(3), 1802-1810. https://doi.org/10.1002/2017JD027307

Andersen, L. N., Laub, P. & Rojas-Nandayapa, L. (2018). Efficient simulation for dependent rare events with applications to extremes. Methodology and Computing in Applied Probability, 20(1), 385-409. https://doi.org/10.1007/s11009-017-9557-4

Zhang, Z., Klausen, L. H., Chen, M. & Dong, M. (2018). Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene-Based Nanomaterials. Small, 14(48), Article 1801983. https://doi.org/10.1002/smll.201801983

Chen, M. (2018). Electrohydrodynamics based functional nanofibers as 3D nano-biointerfaces. Abstract from Ringberg Symposium, Kreuth, Germany. https://pfringberg2018.wordpress.com/schedule/

Chen, M. (2018). Electrohydrodynamics Based Functional Nanofibers as Three-Dimensional Nano-Biointerfaces. Abstract from 2018 MRS Spring Meeting & Exhibit, Phoenix, United States. https://mrsspring2018.zerista.com/event/member/464601

Tarpø, C. L. G., Chen, M., Nygaard, J. V., Waagensen, L., Forman, A., Danielsen, C. C., Taskin, M. B., Andersson, K.-E. & Axelsen, S. M. (2018). Electrospun biodegradable microfibers induce new collagen formation in a rat abdominal wall defect model: A possible treatment for pelvic floor repair? Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 106(2), 680-688. https://doi.org/10.1002/jbm.b.33875

Hollensen, A. K., Andersen, S., Hjorth, K., Bak, R. O., Hansen, T. B., Kjems, J., Aagaard, L., Damgaard, C. K. & Mikkelsen, J. G. (2018). Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. Molecular Therapy - Nucleic Acids, 13, 365-375. https://doi.org/10.1016/j.omtn.2018.09.009

Hansen, L. K., Balog, R., Cassidy, A., Jørgensen, J. H., Grubisic Cabo, A., Trotochaud, L., Bluhm, H. & Hornekær, L. (2018). Enhancing Graphene Protective Coatings by Hydrogen-Induced Chemical Bond Formation. ACS Applied Nano Materials, 1(9), 4509–4515. https://doi.org/10.1021/acsanm.8b00610

Ebbesen, M. & Skydsgaard, M. A. (2018). En stukket gris. In M. A. Skydsgaard & K. H. Nielsen (Eds.), Videnskab er lidenskab: Med forskere på arbejde (pp. 49-66). Aarhus Universitetsforlag.