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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Simonsen, M., Thomsen, R., Christensen, M. H. & Pedersen, C. N. S. (2011). GPU-Accelerated High-Accuracy Molecular Docking using Guided Differential Evolution. In GECCO'11 Proceedings of the 13th annual conference on Genetic and evolutionary computation (pp. 1803-1810). Association for Computing Machinery. https://doi.org/10.1145/2001576.2001818

Krüger, A. C., Nielsen, M. M., Kjems, J., Besenbacher, F. & Birkedal, V. (2011). G-quadruplex structures in telomeric DNA studied with single molecule FRET microscopy. Poster session presented at Third International Meeting on G-Quadruplex and G-assembly, Sorrento, Italy. http://f1000.com/posters/browse?conferenceId=297

Kongsfelt, M. S., Sørensen, J. V., Ceccato, M., Nilsson, L., Jørgensen, B., Hornekær, L., Pedersen, S. U. & Daasbjerg, K. (2011). Graphene, Diazonium Chemistry and Triazenes. Poster session presented at 9th iNANO Annual Meeting, Aarhus, Denmark.

Yu, M., Wang, J., Mura, M., Meng, Q.-Q., Xu, W., Gersen, H., Lægsgaard, E., Stensgaard, I., Kelly, R. E. A., Kjems, J., Linderoth, T. R., Kantorovich, L. N. & Besenbacher, F. (2011). Homochiral Xanthine Quintet Networks Self-Assembled on Au(111) Surfaces. ACS Nano, 5(8), 6651-6660. https://doi.org/10.1021/nn202157m

Runager, K., Basaiawmoit, R. V., Deva, T., Andreasen, M., Valnickova, Z., Sørensen, C. S., Karring, H., Thøgersen, I. B., Christiansen, G., Underhaug, J., Kristensen, T., Nielsen, N. C., Klintworth, G. K., Otzen, D. E. & Enghild, J. J. (2011). Human Phenotypically Distinct TGFBI Corneal Dystrophies Are Linked to the Stability of the Fourth FAS1 Domain of TGFBIp. Journal of Biological Chemistry, 286(7), 4951-8. https://doi.org/10.1074/jbc.M110.181099

Scavenius, C., Ghodke, S., Otzen, D. E. & Enghild, J. J. (2011). Hydrogen exchange mass spectrometry as an analytical tool for the analysis of amyloid fibrillogenesis. International Journal of Mass Spectrometry, 302(1-3), 167-173. https://doi.org/10.1016/j.ijms.2010.10.001

Hobolth, A., Dutheil, J., Hawks, J., Schierup, M. H. & Mailund, T. (2011). Incomplete lineage sorting patterns among human, chimpanzee and orangutan suggest recent orangutan speciation and widespread selection. Genome Research, 21(3), 349-356. https://doi.org/10.1101/gr.114751.110

Simonsen, M., Mailund, T. & Pedersen, C. N. S. (2011). Inference of Large Phylogenies Using Neighbour-Joining. Biomedical Engineering Systems and Technologies, 127(5), 334-344. https://doi.org/10.1007/978-3-642-18472-7_26

Andersen, L. N. (2011). Inferring Population Histories In The IM-model Using Site Pattern Analysis. Poster session presented at SMBE 2011, Kyoto, Japan.

Keller, A., Fritzsche, M., Yu, Y.-P., Liu, Q., Li, Y.-M., Dong, M. & Besenbacher, F. (2011). Influence of Hydrophobicity on the Surface-Catalyzed Assembly of the Islet Amyloid Polypeptide. ACS Nano. https://doi.org/10.1021/nn1031998

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Kalinka Hansen