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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Conzelmann, C., Müller, J. A., Perkhofer, L., Sparrer, K. M. J., Zelikin, A. N., Münch, J. & Kleger, A. (2020). Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine, Journal of the Royal College of Physicians of London, 20(6), e218-e221. https://doi.org/10.7861/clinmed.2020-0351

Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289

Sun, D., Zhang, Y., Liu, Y., Wang, Z., Chen, X., Meng, Z., Kang, S., Zheng, Y., Cui, L., Chen, M., Dong, M. & Hu, B. (2020). In-situ homodispersely immobilization of Ag@AgCl on chloridized g-C₃N₄ nanosheets as an ultrastable plasmonic photocatalyst. Chemical Engineering Journal, 384, Article 123259. https://doi.org/10.1016/j.cej.2019.123259

Gao, Q., Zhang, J., Chen, C., Chen, M., Sun, P., Du, W., Zhang, S., Liu, Y., Zhang, R., Bai, M., Fan, C., Wu, J., Men, T. & Jiang, X. (2020). In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection. ACS Nano, 14(4), 3980-3990. https://doi.org/10.1021/acsnano.9b07896

Moller Sonderskov, S., Hyldgaard Klausen, L., Amland Skaanvik, S., Han, X. & Dong, M. (2020). In situ Surface Charge Density Visualization of Self-assembled DNA Nanostructures after Ion Exchange. ChemPhysChem, 21(13), 1474-1482. https://doi.org/10.1002/cphc.201901168

Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., PCAWG Drivers and Functional Interpretation Working Group, Reimand, J. & PCAWG Consortium (2020). Integrative pathway enrichment analysis of multivariate omics data. Nature Communications, 11(1), Article 735. https://doi.org/10.1038/s41467-019-13983-9