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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Harms, M., Fabech Hansson, R., Gilg, A., Almeida-Hernández, Y., Löffler, J., Rodríguez-Alfonso, A., Habib, M. M. W., Albers, D., Ahmed, N. S., Abadi, A. H., Winter, G., Rasche, V., Beer, A. J., Weidinger, G., Preising, N., Ständker, L., Wiese, S., Sanchez-Garcia, E., Zelikin, A. N. & Münch, J. (2023). Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability. Journal of Medicinal Chemistry, 66(22), 15189-15204. https://doi.org/10.1021/acs.jmedchem.3c01128

Nielsen, K. H. (2023). Dilemma i dybhavet. Weekendavisen, Sektion 4 (Ideer), 5.

Nasrollahzadeh, F., Spotti, M. J., Skov, K., Mekonen, T., Chen, M. & Martinez, M. M. (2023). Dispersion of low concentration of particulate or fibrillated protein fillers into plant protein melts and their impact on the elasticity and tenderness gap of plant-based foods. Food Hydrocolloids, 144, Article 108985. https://doi.org/10.1016/j.foodhyd.2023.108985

Nielsen, K. H. (2023). Dronte 2.0. Weekendavisen, Sektion 4 (Ideer), 12.

Somavarapu, A. K., Kleijwegt, G., Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E. (2023). Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions. Chemical Science, 14(11), 3030-3047. https://doi.org/10.1039/d2sc05534a

Xie, Z., Dionysiou, D. D., Luo, S., Chen, M. & Wei, Z. (2023). Dual-reaction center catalyst based on common metals Cu-Mg-Al for synergistic peroxymonosulfate adsorption-activation in Fenton-like process. Applied Catalysis B: Environment and Energy, 327, Article 122468. https://doi.org/10.1016/j.apcatb.2023.122468

Zelikin, A. N., Andersen, E. S. & Städler, B. (2023). Editorial for the Special Issue 'Synthetic Biology and Biomimicry'. Small, 19(13), Article 2301160. https://doi.org/10.1002/smll.202301160