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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Jiang, Z., Zhang, S., Yang, C., Kjems, J., Huang, Y., Besenbacher, F. & Dong, MD. (2015). Serum induced degradation of 3D DNA box origami observed by high speed atomic force microscope. Nano Research, 8(7), 2170-2178. https://doi.org/10.1007/s12274-015-0724-z

Jiang, Z., Zhang, S., Yang, C., Zadegan, R. M., Kjems, J., Huang, Y., Besenbacher, F. & Dong, M. (2015). Serum-induced degradation of 3D DNA box origami observed with high-speed atomic force microscopy (vol 8, pg 2170, 2015). Nano Research, 8(10), 3446-3446. https://doi.org/10.1007/s12274-015-0848-1

Jepsen, M. DE., Sørensen, R. S., Andersen, E. S., Kjems, J. & Birkedal, V. (2015). Single Molecule FRET Analysis of the Closed and Open States of a DNA Origami Box. Biophysical Journal, 108(2, suppl. 1), 175a. https://doi.org/10.1016/j.bpj.2014.11.968

Nielsen, K. H., Balling, G., Hope, T. & Nakamura, M. (2015). Sipping Science: The Interpretative Flexibility of Science Cafés in Denmark and Japan. East Asian Science, Technology and Society: an international journal, 9(1), 1-21. https://doi.org/10.1215/18752160-2832109

Wang, J., Cao, Y., Li, Q., Liu, L. & Dong, M. (2015). Size Effect of Graphene Oxide on Modulating Amyloid Peptide Assembly. Chemistry: A European Journal, 21(27), 9632-9637. https://doi.org/10.1002/chem.201500577

Heymann, M., Nielsen, K. H., Nielsen, H. & Knudsen, H. (2015). Small state versus Superpower: Science and Geopolitics in Greenland in the early Cold War. In J. van Dongen (Ed.), Cold War Science and the Transatlantic Circulation of Knowledge (pp. 235-263). Brill.

Takizawa, S., Breitenbach, T., Westberg, M., Holmegaard, L., Gollmer, A., Jensen, R. L., Murata, S. & Ogilby, P. R. (2015). Solvent dependent photosensitized singlet oxygen production from an Ir(III) complex: pointing to problems in studies of singlet-oxygen-mediated cell death. Photochemical & Photobiological Sciences, 14(10), 1831-1843. https://doi.org/10.1039/C5PP00230C

Venø, M. T., Hansen, T. B., Venø, S. T., Clausen, B. H., Grebing, M., Finsen, B., Holm, I. E. & Kjems, J. (2015). Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biology, 16, Article 16:245. https://doi.org/10.1186/s13059-015-0801-3

Hirsch, C., Delaney, G. & Schmidt, V. (2015). Stationary Apollonian Packings. Journal of Statistical Physics, 161(1), 35-72.

Mohammad-Beigi, H., Shojaosadati, S. A., Marvian, A. T., Pedersen, J. N., Klausen, L. H., Christiansen, G., Pedersen, J. S., Dong, M., Morshedi, D. & Otzen, D. E. (2015). Strong interactions with polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA NPs) alter α-synuclein conformation and aggregation kinetics. Nanoscale, 7, 19627-19640. https://doi.org/10.1039/c5nr05663b

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Kalinka Hansen