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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Kongsfelt, M. S., Ceccato, M., Nilsson, L., Jørgensen, B., Hornekær, L., Pedersen, S. U. & Daasbjerg, K. (2010). Chemical Modifications of Graphene using Diazonium Chemistry. Poster session presented at The Annual World Conference on Carbon 2010, Clemson, United States.

Mittnacht, U., Hartmann, H., Hein, S., Oliveira, H., Dong, M., Pêgo, A. P., Kjems, J., Howard, K. A. & Schlosshauer, B. (2010). Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth. Nano Letters, 10(10), 3933-9. https://doi.org/10.1021/nl1016909

Beerens, N. & Kjems, J. (2010). Circularization of the HIV-1 genome facilitates strand transfer during reverse transcription. RNA, 16(6), 1226-35. https://doi.org/10.1261/rna.2039610

Kamma-Lorger, C. S., Boote, C., Hayes, S., Moger, J., Burghammer, M., Knupp, C., Quantock, A. J., Sorensen, T., Di Cola, E., White, N., Young, R. D. & Meek, K. M. (2010). Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology, 169(3), 424-30. https://doi.org/10.1016/j.jsb.2009.11.004

Poulsen, H. V., Canibe, N., Finster, K. & Jensen, B. B. (2010). Concentration of volatile sulphur-containing compounds along the gastrointestinal tract of pigs fed a high-sulphur or a low-sulphur diet. Livestock Science, 133(1-3), 128-131. https://doi.org/10.1016/j.livsci.2010.06.043

Nielsen, K. H. (2010). Confidentiality vs. publicity: Emerging tensions in military-science collaborations during the Cold War. Abstract from 4th International Conference of the European Society for the History of Science, Barcelona, Spain.

Ng, M. L., Balog, R., Hornekær, L., Preobrajenski, A. B., Vinogradov, N. A., Mårtensson, N. & Schulte, K. (2010). Controlling Hydrogenation of Graphene on Transition Metals. Journal of Physical Chemistry C, 114(43), 18559-18565 . https://doi.org/10.1021/jp106361y

Bayratarov, E., Finster, K., Price, R. E., Hubert, C. & Ferdelman, T. G. (2010). Controls on sulfate reduction in shallow submarine hydrothermal CO2-venting sediments. Poster session presented at European Geological Union Conference, Milos Island, Greece.

Mapendano, C. K., Lykke-Andersen, S., Kjems, J., Bertrand, E. & Jensen, T. H. (2010). Crosstalk between mRNA 3’ end processing and transcription initiation. Molecular Cell, 40, 410-422.

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