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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Lin, S., Liu, H., Svenningsen, E. B., Pedersen, C., Nørby, P., Tørring, T. & Poulsen, T. (2019). Diversity Focused Semisyntheses of Tetronate Polyether Ionophores. ChemRxiv. https://chemrxiv.org/articles/Diversity_Focused_Semisyntheses_of_Tetronate_Polyether_Ionophores/8299715

Nielsen, K. H. (2019). Dommedag. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2019). Dommedagsuret tikker: Der er kun to minutter tilbage. Avisen Danmark, Sektion 1, 16.

Wang, Y., Wang, Z., Yang, Q., Hua, A., Ma, S., Zhang, Z. & Dong, MD. (2019). Edge-oriented MoS2 supported on nickel/carbon core–shell nanospheres for enhanced hydrogen evolution reaction performance. New Journal of Chemistry, 43(16), 6146-6152. https://doi.org/10.1039/c9nj00612e, https://doi.org/10.1039/C9NJ00612E

Costard, L. S., Neubert, V., Venø, M. T., Su, J., Kjems, J., Connolly, N. M. C., Prehn, J. H. M., Schratt, G., Henshall, D. C., Rosenow, F. & Bauer, S. (2019). Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression. Brain Stimulation, 12(6), 1390-1401. https://doi.org/10.1016/j.brs.2019.06.009

Jin, L., Ye, J., Wang, Y., Qian, X. & Dong, M. (2019). Electrospinning Synthesis of ZIF-67/PAN Fibrous Membrane with High-capacity Adsorption for Malachite Green. Fibers and Polymers, 20(10), 2070-2077. https://doi.org/10.1007/s12221-019-1196-7

Li, T. L., Wang, Z., You, H., Ong, Q., Varanasi, V. J., Dong, M., Lu, B., Paşca, S. P. & Cui, B. (2019). Engineering a Genetically Encoded Magnetic Protein Crystal. Nano Letters, 19(10), 6955-6963. https://doi.org/10.1021/acs.nanolett.9b02266

Su, C., Tripathi, M., Yan, Q. B., Wang, Z., Zhang, Z., Hofer, C., Wang, H., Basile, L., Su, G., Dong, M., Meyer, J. C., Kotakoski, J., Kong, J., Idrobo, J. C., Susi, T. & Li, J. (2019). Engineering single-atom dynamics with electron irradiation. Science Advances, 5(5), Article eaav2252. https://doi.org/10.1126/sciadv.aav2252

Klein, W. P., Thomsen, R. P., Turner, K. B., Walper, S. A., Vranish, J., Kjems, J., Ancona, M. G. & Medintz, I. L. (2019). Enhanced Catalysis from Multienzyme Cascades Assembled on a DNA Origami Triangle. ACS Nano, 13(12), 13677-13689. https://doi.org/10.1021/acsnano.9b05746