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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Zhao, H., Song, X., Aslan, H., Liu, B., Wang, J., Wang, L., Besenbacher, F. & Dong, M. (2016). Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. Physical Chemistry Chemical Physics, 18(21), 14168-14171. https://doi.org/10.1039/c6cp00112b

Braun, S., Morono, Y., Littmann, S., Kuypers, M. M. M., Aslan, H., Dong, MD., Jørgensen, B. B. & Lomstein, B. A. (2016). Size and Carbon Content of Sub-seafloor Microbial Cells at Landsort Deep, Baltic Sea. Frontiers in Microbiology, 7(AUG), 1-13. Article 1375. https://doi.org/10.3389/fmicb.2016.01375

Nielsen, K. H. (2016). Small State Preoccupations: Science and Technology in the Pursuit of Modernization, Security, and Sovereignty in Greenland. In R. E. Doel, K. C. Harper & M. Heymann (Eds.), Exploring Greenland: Cold War Science and Technology on Ice (pp. 47-71). Palgrave Macmillan.

Bregnhøj, M., Krægpøth, M. V., Sørensen, R. J., Westberg, M. & Ogilby, P. R. (2016). Solvent and Heavy-Atom Effects on the O₂(X³Σ_g^-) → O₂(b¹Σ_g⁺) Absorption Transition. The Journal of Physical Chemistry Part A, 120(42), 8285-8296. https://doi.org/10.1021/acs.jpca.6b08035

Bregnhøj, M., Westberg, M., Jensen, F. & Ogilby, P. R. (2016). Solvent-dependent singlet oxygen lifetimes: temperature effects implicate tunneling and charge-transfer interactions. Physical Chemistry Chemical Physics, 18(33), 22946-22961. https://doi.org/10.1039/C6CP01635A

Hjorth, C. F., Norrman, M., Wahlund, P.-O., Benie, A. J., Petersen, B. O., Jessen, C. M., Pedersen, T. Å., Vestergaard, K., Steensgaard, D. B., Pedersen, J. S., Naver, H., Hubálek, F., Poulsen, C. & Otzen, D. (2016). Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. Journal of Pharmaceutical Sciences, 105(4), 1376-1386. https://doi.org/10.1016/j.xphs.2016.01.003

Thingholm, B., Schattling, P., Zhang, Y. & Stadler, B. M. (2016). Subcompartmentalized Nanoreactors as Artificial Organelle with Intracellular Activity. Small, 12(13), 1806–1814 .

Kofler, R., Langmüller, A. M., Nouhaud, P., Otte, K. A. & Schlötterer, C. (2016). Suitability of different mapping algorithms for genome-wide polymorphism scans with pool-seq data. G3: Genes, Genomes, Genetics, 6(11), 3507-3515. https://doi.org/10.1534/g3.116.034488

Poser, A., Vogt, C., Knoeller, K., Sorokin, D. Y., Finster, K. W. & Richnow, H.-H. (2016). Sulfur and Oxygen Isotope Fractionation During Bacterial Sulfur Disproportionation Under Anaerobic Haloalkaline Conditions. Geomicrobiology Journal, 33(10), 934-941. https://doi.org/10.1080/01490451.2015.1128993

Xia, D., Li, Q., Xue, Q., Liang, C. & Dong, M. (2016). Super flexibility and stability of graphene nanoribbons under severe twist. Physical Chemistry Chemical Physics, 18(27), 18406-18413. https://doi.org/10.1039/c6cp02580c

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Kalinka Hansen