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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Hirsch, C. (2016). Bounded-hop percolation and wireless communication. Journal of Applied Probability, 53(3), 833-845.

Nielsen, K. H. (2016). Byte. Weekendavisen, Ideer, 10.

Mazzorana, M., Hussain, R. & Sorensen, T. (2016). Ca-Dependent Folding of Human Calumenin. PLoS One, 11(3), e0151547. Article e0151547. https://doi.org/10.1371/journal.pone.0151547

Nielsen, H. & Nielsen, K. H. (2016). Camp Century - Cold War City Under the Ice. In R. E. Doel, K. E. Harper & M. Heymann (Eds.), Exploring Greenland: Cold War Science and Technology on Ice (1 ed., pp. 195-216). Palgrave Macmillan.

Boote, C., Palko, J. R., Sorensen, T., Mohammadvali, A., Elsheikh, A., Komáromy, A. M., Pan, X. & Liu, J. (2016). Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Molecular Vision, 22, 503-517.

Li, Y., Liang, H., Zhao, H., Chen, D., Liu, B., Fuhs, T. & Dong, M. (2016). Characterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy. Journal of Nanomaterials, 2016, Article 5463201. https://doi.org/10.1155/2016/5463201

Gaglianone, N., Hvam, M. L., Aslan, H., Dong, M., Howard, K. & Ho, Y.-P. (2016). Chip-Free Microscale-Incubator-Based Synthesis of Chitosan-Based Gene Silencing Nanoparticles. Particle & Particle Systems Characterization, 33(5), 279-285. https://doi.org/10.1002/ppsc.201500225