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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, K. H. (2018, Jan 7). Bioteknologi - fra øl og gærkulturer til gensplejsning. Videnskab.dk. https://videnskab.dk/naturvidenskab/bioteknologi-fra-oel-og-gaerkulturer-til-gensplejsning

Nielsen, K. H. (2018). Book Review: Helga Nowotny, The cunning of uncertainty. Public Understanding of Science, 260.

Li, S., Zhu, T., Dong, L. & Dong, M. (2018). Boosted visible light photodegradation activity of boron doped rGO/g-C₃N₄ nanocomposites: the role of C-O-C bonds. New Journal of Chemistry, 42(21), 17644-17651. https://doi.org/10.1039/c8nj03571g

Gao, S., Hu, X., Xu, F., Gao, C., Xiong, K., Zhao, X., Chen, H., Zhao, S., Wang, M., Fu, D., Zhao, X., Bai, J., Mao, L., Li, B., Wu, S., Wang, J., Li, S., Yang, H., Bolund, L. & Pedersen, C. N. S. (2018). BS-virus-finder: virus integration calling using bisulfite sequencing data. GigaScience, 7(1), 1-7. https://doi.org/10.1093/gigascience/gix123

Song, W., Yang, C., Svend Le, D. Q., Zhang, Y. & Kjems, J. (2018). Calcium-microRNA Complexes Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells. A C S Applied Materials and Interfaces, 10(9), 7756-7764. https://doi.org/10.1021/acsami.7b18289

Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, J. R. & Otzen, D. E. (2018). Can a Charged Surfactant Unfold an Uncharged Protein? Biophysical Journal, 115(11), 2081-2086. https://doi.org/10.1016/j.bpj.2018.10.022

Nielsen, K. H. (2018). Cannabis. Weekendavisen, Sektion 4 (Ideer), 10.

Wang, Y., Xia, Q., Bai, X., Ge, Z., Yang, Q., Yin, C., Kang, S., Dong, M. & Li, X. (2018). Carbothermal activation synthesis of 3D porous g-C₃N₄/carbon nanosheets composite with superior performance for CO₂ photoreduction. Applied Catalysis B: Environment and Energy, 239, 196-203. https://doi.org/10.1016/j.apcatb.2018.08.018

Vu Quang, H., Chang, C.-C., Song, P., Hauge, E. M. & Kjems, J. (2018). Caveolae-mediated mesenchymal stem cell labelling by PSS-coated PLGA PFOB nano-contrast agent for MRI. Theranostics, 8(10), 2657-2671. https://doi.org/10.7150/thno.23206

Larsen, M. T., Rawsthorne, H., Schelde, K. K., Dagnæs-Hansen, F., Cameron, J. & Howard, K. (2018). Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement. Journal of Controlled Release, 287, 132-141. https://doi.org/10.1016/j.jconrel.2018.07.023

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Kalinka Hansen