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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Bertl, J., Guo, Q., Juul, M., Besenbacher, S., Nielsen, M. M., Hornshøj, H., Pedersen, J. S. & Hobolth, A. (2018). A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data. BMC Bioinformatics , 19(147), Article 147. https://doi.org/10.1186/s12859-018-2141-2

Nielsen, K. H. (2018). Aspergers. Weekendavisen, Sektion 4 (Ideer), 10.

Finster, K. & Nielsen, N. I. W. (2018). Astrobiologi. Naturhistorisk Museum. Natur og Museum Vol. 57 No. 2

Wu, Z., Troll, J., Jeong, H.-H., Wei, Q., Stang, M., Ziemssen, F., Wang, Z., Dong, M., Schnichels, S., Qiu, T. & Fischer, P. (2018). A swarm of slippery micropropellers penetrates the vitreous body of the eye. Science Advances, 4(11), Article 4388. https://doi.org/10.1126/sciadv.aat4388

Nielsen, K. H. (2018). Balladen om bitcoin: Måske er penge i lommen alligevel bedre end bitcoin... Fyens Stiftstidende. https://www.fyens.dk/debat/Maaske-er-penge-i-lommen-alligevel-bedre-end-bitcoin/artikel/3243147

Eriksen, C. B. (2018). Beneath the visible: Nature and the sub-visible world in early modern microscopy.

Olesen, M. T. J., Winther, A., Fejerskov, B., Dagnæs-Hansen, F., Simonsen, U. & Zelikin, A. N. (2018). Bi‐Enzymatic Embolization Beads for Two‐Armed Enzyme‐Prodrug Therapy. Advanced Therapeutics, 1(4), Article 1800023. https://doi.org/10.1002/adtp.201800023

Prabha, R. D., Kraft, D. C. E., Harkness, L., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M. (2018). Bioactive Nano-fibrous Scaffold for Vascularized Craniofacial Bone Regeneration. Journal of Tissue Engineering and Regenerative Medicine, 12(3), e1537-e1548. https://doi.org/10.1002/term.2579

Nielsen, K. H. (2018). Biodiversitet. Weekendavisen, Sektion 4 (Ideer), 10.

Loudon, C.-M., Nicholson, N., Finster, K., Leys, N., Byloos, B., Van Houdt, R., Rettberg, P., Moeller, R., Fuchs, F. M., Demets, R., Krause, J., Vukich, M., Mariani, A. & Cockell, C. (2018). BioRock: new experiments and hardware to investigate microbe-mineral interactions in space. International Journal of Astrobiology, 17(4), 303-313. https://doi.org/10.1017/S1473550417000234

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