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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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McGovern, R. E., Snarr, B. D., Lyons, J. A., McFarlane, J., Whiting, A. L., Paci, I., Hof, F. & Crowley, P. B. (2015). Structural study of a small molecule receptor bound to dimethyllysine in lysozyme. Chemical Science, 6(1), 442-449. https://doi.org/10.1039/c4sc02383h

Tian, P., Boomsma, W., Wang, Y., Otzen, D., Jensen, M. H. & Lindorff-Larsen, K. (2015). Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation. Journal of the American Chemical Society, 137(1), 22-25. https://doi.org/10.1021/ja5093634

Jensen, R. K., Plum, M., Tjerrild, L., Jakob, T., Spillner, E. & Andersen, G. R. (2015). Structure of the omalizumab Fab. Acta Crystallographica Section F: Structural Biology Communications, 71(Pt 4), 419-426. https://doi.org/10.1107/S2053230X15004100

Estrela, N., Franquelim, H. G., Lopes, C., Tavares, E., Macedo, J. A., Christiansen, G., Otzen, D. E. & Melo, E. P. (2015). Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure. Proteins: Structure, Function, and Bioinformatics, 83(11), 2039-2051. https://doi.org/10.1002/prot.24921

Wang, Z., Li, P., Chen, Y., Liu, J., Zhang, W., Guo, Z., Dong, MD. & Li, Y. (2015). Synthesis, characterization and electrical properties of silicon-doped graphene films. Journal of Materials Chemistry C, 3, 6301-6306. https://doi.org/10.1039/c5tc00563a

Schiølin, K. (2015). Teknologipessimisme: Træk af slægtskabet mellem den klassiske teknologifilosofi og den pessimistiske viljesmetafysik: Schopenhauer, Nietzsche, Jünger og Heidegger . Aarhus Universitet, Institut for Kommunikation og Kultur - Informationsvidenskab.

Li, D., Stansfeld, P. J., Sansom, M. S. P., Keogh, A., Vogeley, L., Howe, N., Lyons, J. A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N. A., Cherezov, V., Liu, W., Bandaru, S. ... Caffrey, M. (2015). Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nature Communications, 6, Article 10140. https://doi.org/10.1038/ncomms10140

Madsen, J., Pihl, R., Møller, A. H., Tranberg Madsen, A., Otzen, D. & Andersen, K. K. (2015). The anionic biosurfactant rhamnolipid does not denature industrial enzymes. Frontiers in Microbiology, 6, Article 292. https://doi.org/10.3389/fmicb.2015.00292

Nielsen, K. H. (2015). The Bohr atom bound in cloth: Textual exposition of quantum theory in popular science books, 1918-1924. In F. Aaserud & H. Kragh (Eds.), One Hundred Years of the Bohr Atom: Proceedings from a Conference (Vol. 1, pp. 141-158). Det Kongelige Danske Videnskabernes Selskab.

Zhang, P., Hou, X., He, Y., Peng, Q. & Dong, M. (2015). The effects of surface group functionalization and strain on the electronic structures of two-dimensional silicon carbide. Chemical Physics Letters, 628, 60-65. https://doi.org/10.1016/j.cplett.2015.03.031

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