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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. & Andersen, E. S. (2017). Incentives for responsible data management: The case of Labbook, an electronic laboratory notebook system. Poster session presented at 5th World Conference on Research Integrity, Amsterdam, Netherlands.

Ebbesen, K. K., Hansen, T. B. & Kjems, J. (2017). Insights into circular RNA biology. RNA Biology, 14(8), 1035-1045. https://doi.org/10.1080/15476286.2016.1271524

Qian, X., Lin, Z., Guan, L., Li, Q., Wang, Y., Zhang, M. & Dong, M. (2017). In Situ Probing the Relaxation Properties of Ultrathin Polystyrene Films by Using Electric Force Microscopy. Nanoscale Research Letters, 12, Article 257. https://doi.org/10.1186/s11671-017-2019-7

Kristoffersen, E. L., Jørgensen, A. G., Jørgensen, L. A., Jensen, P. W., W Byl, J. A., Osheroff, N., Andersen, A. H., Stougaard, M., Ho, Y.-P. & Knudsen, B. R. (2017). Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events. Nucleic Acids Research, 45(13), 7855-7869. https://doi.org/10.1093/nar/gkx480

Fay, F., Hansen, L., Hectors, S. J. C. G., Sanchez-Gaytan, B. L., Zhao, Y., Tang, B.-J., Munitz, J., Alaarg, A., Braza, M. S., Gianella, A., Aaronson, S. A., Reiner, T., Kjems, J., Langer, R., Hoeben, F. J. M., Janssen, H. M., Calcagno, C., Strijkers, G. J., Fayad, Z. A. ... Mulder, W. J. M. (2017). Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging. Bioconjugate Chemistry, 28(5), 1413-1421. https://doi.org/10.1021/acs.bioconjchem.7b00086

Nielsen, K. H. (2017). Italesættelse. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2017). Kapitalocæn. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2017). Kemoterapi. Weekendavisen, Sektion 4 (Ideer), 10.

Yang, G., Liu, L., Wang, J., Bortolini, C. & Dong, M. (2017). Light-driven porphyrin modulating fibrillation of hIAPP(20-29) peptide. Journal of Colloid and Interface Science, 495, 37-43. https://doi.org/10.1016/j.jcis.2017.01.089